Epigenetic regulation of Epstein-Barr virus: From bench to bedside

被引：1

作者：

Gao, Xiao ^{[1
]}

Yang, Hao-Xu ^{[1
]}

Cheng, Shu ^{[1
]}

Cai, Hua-Man ^{[1
]}

Xiong, Jie ^{[1
]}

Zhao, Wei-Li ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Inst Hematol, Natl Res Ctr Translat Med Shanghai, Ruijin Hosp,State Key Lab Med Genom,Sch Med, Shanghai, Peoples R China

[2] Lab Mol Pathol, Pole Rech Sinofrancais Sci Vivant et Genom, Shanghai, Peoples R China

来源：

CLINICAL AND TRANSLATIONAL DISCOVERY | 2024年 / 4卷 / 05期

基金：

中国国家自然科学基金;

关键词：

epigenetic; Epstein-Barr virus; histone; immune escape; metabolic reprogramming; pathogenesis; targeted therapy; NK/T-CELL LYMPHOMA; NASOPHARYNGEAL CARCINOMA; PRIMARY IMMUNODEFICIENCIES; GENE-EXPRESSION; PHASE-II; PROTEIN; TRANSCRIPTION; REVEALS; REACTIVATION; PROMOTERS;

D O I：

10.1002/ctd2.357

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

BackgroundEpstein-Barr virus (EBV) is a double-stranded DNA herpesvirus and establishes life-long infection in 95% of the world's populations.Main bodyEBV is critically involved in multiple diseases. Aberrant signaling pathways, immune escape, and metabolic reprogramming play essential roles in EBV-mediated pathogenesis. However, the underlying mechanisms have not yet been fully elucidated. Here we reviewed recent advances on the epigenetic regulation of EBV pathogenesis, which may translate to potential therapeutic strategies in EBV-associated diseases.ConclusionGrowing evidence has suggested that viral infections reconstruct epigenome to modulate gene expression both in the host and the virus levels. EBV acts as an epigenetic driver in carcinogenesis and mainly refers to DNA methylation, RNA methylation, histone modification, chromatin accessibility, and the three-dimensional (3D) genome structure. image

引用

页数：13

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