Study of a precise treatment protocol for patients with consciousness disorders based on the brain network analysis of functional magnetic resonance imaging

被引：0

作者：

Wang, Pingzhi ^{[1
]}

Xiang, Jie ^{[2
]}

Niu, Yan ^{[2
]}

Wei, Jing ^{[2
]}

Lan, Caiqin ^{[1
]}

Li, Xiangping ^{[1
]}

Xu, Liying ^{[1
]}

Yin, Yajie ^{[1
]}

Wang, Hongxiong ^{[1
]}

Zhang, Tao ^{[1
]}

Yang, Lei ^{[1
]}

Xing, Hao ^{[1
]}

Fan, Shasha ^{[1
]}

Niu, Qing ^{[1
]}

Kang, Huicong ^{[1
,3
]}

Liang, Ying ^{[1
]}

机构：

[1] Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Hosp 3, Taiyuan, Peoples R China

[2] Taiyuan Univ Technol, Coll Comp Sci & Technol, Coll Data Sci, Taiyuan, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan, Peoples R China

来源：

FRONTIERS IN NEUROSCIENCE | 2024年 / 18卷

关键词：

disorders of consciousness; brain network; functional magnetic resonance imaging; olfactory cortex; repeated transcranial magnetic stimulation; occipital lobe; ANTERIOR FOREBRAIN MESOCIRCUIT; PREDICTS RECOVERY; DEFAULT MODE; CONNECTIVITY; STIMULATION; PRECUNEUS; CORTEX; LEVEL; RTMS;

D O I：

10.3389/fnins.2024.1443478

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Objective How to conduct objective and accurate individualized assessments of patients with disorders of consciousness (DOC) and carry out precision rehabilitation treatment technology is a major rehabilitation problem that needs to be solved urgently.Methods In this study, a multi-layer brain network was constructed based on functional magnetic resonance imaging (fMRI) to analyze the structural and functional brain networks of patients with DOC at different levels and to find regulatory targets (imaging markers) with recovery potential for DOC. Then repeated transcranial magnetic stimulation (rTMS) was performed in DOC patients to clinically validate.Results The brain network connectivity of DOC patients with different consciousness states is different, and the most obvious brain regions appeared in the olfactory cortex and precuneus. rTMS stimulation could effectively improve the consciousness level of DOC patients and stimulate the occipital lobe (specific regions found in this study) and the dorsolateral prefrontal cortex (DLPFC), and both parts had a good consciousness recovery effect.Conclusion In clinical work, personalized stimulation regimen treatment combined with the brain network characteristics of DOC patients can improve the treatment effect.

引用

页数：20

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