Efficient Synthesis of 2-Aryl-4H-Benzo[d][1,3]Oxazin-4-Ones by Copper-Catalyzed Decarboxylation of α-Keto Acids with Anthranilic Acids

被引：2

作者：

Yan, Jiaqi ^{[1
]}

Yang, Zhiyong ^{[1
]}

Guo, Jing ^{[1
]}

Xue, Qiuyan ^{[1
]}

Chen, Ping ^{[1
]}

机构：

[1] Hunan Univ Arts & Sci, Furong Coll, Changde 415000, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 13卷 / 08期

关键词：

2-Aryl-4H-Benzo[d][1,3]oxazin-4-ones; Anthranilic acid; alpha-keto acid; Copper-catalysis; Cyclization; CARBONYLATIVE SYNTHESIS; ACTIVATION; BENZOXAZINONES; CHYMOTRYPSIN; DERIVATIVES; CYCLIZATION; INHIBITION; CHEMISTRY;

D O I：

10.1002/ajoc.202400157

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and facile one-pot approach to the 2-aryl-4H-benzo[d][1,3]oxazin-4-ones using the commercially available anthranilic acids and alpha-keto acids as start materials, and catalyzed by inexpensive CuCl. With this strategy, a broad substrate concerning anthranilic acids and alpha-keto acids also worked well, affording the desired products in good yields.

引用

页数：4

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