Prevalence of celiac disease in systemic lupus erythematosus, sjogren syndrome and systemic sclerosis: A systematic review and meta-analysis

被引：4

作者：

Beas, Renato ^{[1
]}

Altamirano-Farfan, Euler ^{[2
]}

Izquierdo-Veraza, Diego ^{[1
]}

Norwood, Dalton A. ^{[3
]}

Riva-Moscoso, Adrian ^{[4
]}

Godoy, Ambar

Montalvan-Sanchez, Eleazar E. ^{[1
]}

Ramirez, Mirian ^{[5
]}

Guifarro, Daniel A. ^{[6
]}

Kitchin, Emily ^{[7
]}

Fischer, Monika ^{[8
]}

Kurada, Satya ^{[8
]}

机构：

[1] Indiana Univ Sch Med, Dept Med, Indianapolis, IN USA

[2] Univ Nacl San Agustin Arequipa, Arequipa, Peru

[3] Univ Alabama Birmingham, Dept Med, Div Prevent Med, Birmingham, AL USA

[4] Univ Peruana Ciencias Aplicadas, Escuela Med, Lima, Peru

[5] Indiana Univ Sch Med, Ruth Lilly Med Lib, Indianapolis, IN USA

[6] John H Stroger Jr Hosp Cook Cty, Internal Med, Chicago, IL USA

[7] Indiana Univ Sch Med, Div Rheumatol, Indianapolis, IN USA

[8] Indiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN USA

来源：

DIGESTIVE AND LIVER DISEASE | 2024年 / 56卷 / 09期

关键词：

Autoimmune disease; Celiac disease; Systemic lupus erythematosus; Sjogren syndrome; Systemic sclerosis; HEPATIC-DISEASE; TISSUE TRANSGLUTAMINASE; RHEUMATOID-ARTHRITIS; AUTOIMMUNE-DISEASES; AUTOANTIBODIES; DIAGNOSIS; PATHOGENESIS; ANTIBODIES; OVERLAP;

D O I：

10.1016/j.dld.2024.03.015

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Celiac disease (CeD) is an immune-mediated disorder affecting the small bowel, associated with genetic factors and increasing global prevalence. Aim: This study explores the association between CeD, Systemic Lupus Erythematosus (SLE), primary Sjogren syndrome (pSS), and Systemic Sclerosis (SSc). Methods: A systematic review and meta-analysis were conducted following PRISMA guidelines. Searches across multiple databases yielded 2728 articles, with 15 studies selected. Data extraction included study characteristics, prevalence of CeD and CeD antibodies in SLE, pSS, and SSc. Quality assessment utilized the Newcastle-Ottawa Scale. Results: The meta-analysis revealed a pooled prevalence of biopsy-proven CeD in SLE, pSS, and SSc of approximately 3%. Seroprevalence of any CeD antibody in SLE, pSS, and SSc ranged from 3% to 10%. Notably, pSS exhibited the highest prevalence at 5.59%. High heterogeneity was observed in seroprevalence across autoimmune conditions. Quality assessment indicated robust methodological quality in the selected studies. Conclusion: This study highlights a significantly higher prevalence of CeD, especially pSS, compared to the general population. The findings underscore the importance of recognizing elevated CeD antibodies in patients with SLE, pSS and SSc emphasizing the need for early detection and comprehensive care for gastrointestinal symptoms in these conditions. (c) 2024 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：1475 / 1482

页数：8

共 43 条

[1] European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders [J].