Association Between SARS-CoV-2 Viral Load and COVID-19 Vaccination in 4 Phase 3 Trials

被引:3
作者
Janes, Holly [1 ]
Fisher, Leigh H. [1 ]
Kee, Jia Jin [1 ]
Parameswaran, Lalitha [2 ]
Goepfert, Paul A. [3 ]
Falsey, Ann R. [4 ]
Ludwig, James [1 ]
Magaret, Craig A. [1 ]
Gilbert, Peter B. [1 ]
Kublin, James G. [1 ]
Rouphael, Nadine [5 ]
Sobieszczyk, Magdalena E. [6 ]
El Sahly, Hana M. [7 ]
Baden, Lindsey R. [8 ]
Grinsztejn, Beatriz [9 ]
Walsh, Stephen R. [8 ]
Gray, Glenda E. [10 ]
Kotloff, Karen L. [11 ]
Gay, Cynthia L. [12 ]
Greninger, Alexander L. [13 ]
Tapia, Milagritos D. [11 ]
Hammershaimb, E. Adrianne [11 ]
Priddy, Frances H. [14 ]
Green, Justin A. [15 ]
Struyf, Frank [16 ]
Dunkle, Lisa [17 ]
Neuzil, Kathleen M. [18 ]
Corey, Lawrence [1 ]
Huang, Yunda [1 ]
机构
[1] Fred Hutchinson Canc Ctr, Vaccine & Infect Dis Div, 1100 Fairview Ave N,Mail Stop M2-C200, Seattle, WA 98109 USA
[2] NYU, Langone Vaccine Ctr, Grossman Sch Med, New York, NY USA
[3] Univ Alabama Birmingham, Heersink Sch Med, Birmingham, AL USA
[4] Univ Rochester, Infect Dis Div, Rochester, NY USA
[5] Emory Univ, Hope Clin, Atlanta, GA USA
[6] Columbia Univ, Irving Med Ctr, Dept Med, New York, NY USA
[7] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX USA
[8] Brigham & Womens Hosp, Div Infect Dis, Boston, MA USA
[9] Oswaldo Cruz Fdn Fiocruz, Evandro Chagas Natl Inst Infect Dis, Rio De Janeiro, Brazil
[10] South African Med Res Council, Cape Town, South Africa
[11] Univ Maryland, Ctr Vaccine Dev & Global Hlth, Dept Pediat, Sch Med, Baltimore, MD USA
[12] Univ N Carolina, Sch Med, Div Infect Dis, Chapel Hill, NC USA
[13] Univ Washington, Med Ctr, Dept Med Lab Med & Pathol, Seattle, WA USA
[14] Moderna Inc, Cambridge, MA USA
[15] AstraZeneca, Vaccines & Immune Therapies, BioPharmaceut Res & Dev, Cambridge, England
[16] Janssen Res & Dev, Beerse, Belgium
[17] Novavax Inc, Gaithersburg, MD USA
[18] Univ Maryland, Sch Med, Ctr Vaccine Dev & Global Hlth, Baltimore, MD USA
关键词
COVID-19; vaccine; SARS-CoV-2 viral load; transmission; randomized trial; infectiousness;
D O I
10.1093/infdis/jiae400
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Coronavirus disease 2019 (COVID-19) vaccines reduce severe disease and mortality and may lessen transmission, measured by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load (VL). Evaluating vaccine associations in VL at COVID-19 diagnosis in 4 phase 3 randomized, placebo-controlled vaccine trials, July 2020 to July 2021, VL reductions were 2.78 log10 copies/mL (95% confidence interval [CI], 1.38-4.18; n = 60 placebo, 11 vaccine) and 2.12 log10 copies/mL (95% CI, 1.44-2.80; n = 594 placebo, 36 vaccine) for NVX-CoV2373 and mRNA-1273, respectively. Associations were not significant for AZD1222 (0.59 log10 copies/mL; 95% CI, -.19 to 1.36; n = 90 placebo, 78 vaccine) or Ad26.COV2.S (0.23 log10 copies/mL; 95% CI, -.01 to .47; n = 916 placebo, 424 vaccine). Thus, vaccines potentially decreased transmission when ancestral SARS-CoV-2 predominated.Clinical Trials Registration. NCT04470427, NCT04505722, NCT04516746, NCT04611802. Analyses of the initial phase 3 US government-funded COVID-19 vaccine trials reveals that first-generation COVID-19 vaccines may have decreased short-term transmission while the ancestral strain predominated.
引用
收藏
页码:1384 / 1389
页数:6
相关论文
共 50 条
[41]   SARS-CoV-2 Seroconversion and Viral Clearance in Patients Hospitalized With COVID-19: Viral Load Predicts Antibody Response [J].
Masia, Mar ;
Telenti, Guillermo ;
Fernandez, Marta ;
Garcia, Jose A. ;
Agullo, Vanesa ;
Padilla, Sergio ;
Garcia-Abellan, Javier ;
Guillen, Lucia ;
Mascarell, Paula ;
Asenjo, Jose C. ;
Gutierrez, Felix .
OPEN FORUM INFECTIOUS DISEASES, 2021, 8 (02)
[42]   Influence of the Delta Variant and Vaccination on the SARS-CoV-2 Viral Load [J].
Migueres, Marion ;
Dimeglio, Chloe ;
Tremeaux, Pauline ;
Raymond, Stephanie ;
Lhomme, Sebastien ;
Da Silva, Isabelle ;
Oliveira Mendes, Kevin ;
Abravanel, Florence ;
Felice, Marie-Pierre ;
Mansuy, Jean-Michel ;
Izopet, Jacques .
VIRUSES-BASEL, 2022, 14 (02)
[43]   Quantifying the relationship between SARS-CoV-2 viral load and infectiousness [J].
Marc, Aurelien ;
Kerioui, Marion ;
Blanquart, Francois ;
Bertrand, Julie ;
Mitja, Oriol ;
Corbacho-Monne, Marc ;
Marks, Michael ;
Guedj, Jeremie .
ELIFE, 2021, 10
[44]   Understanding the Role of SARS-CoV-2 ORF3a in Viral Pathogenesis and COVID-19 [J].
Zhang, Jiantao ;
Ejikemeuwa, Amara ;
Gerzanich, Volodymyr ;
Nasr, Mohamed ;
Tang, Qiyi ;
Simard, J. Marc ;
Zhao, Richard Y. .
FRONTIERS IN MICROBIOLOGY, 2022, 13
[45]   COVID-19 vaccination is highly effective to prevent SARS-CoV-2 circulation [J].
Mattiuzzi, Camilla ;
Lippi, Giuseppe .
JOURNAL OF INFECTION AND PUBLIC HEALTH, 2022, 15 (04) :395-396
[46]   SARS-CoV-2 infection and COVID-19 in Gaucher disease: indications for vaccination [J].
Laszlo, Marodi .
ORVOSI HETILAP, 2021, 162 (24) :938-942
[47]   Mucosal immune responses to SARS-CoV-2 infection and COVID-19 vaccination [J].
Paul, Mathew J. ;
Hudda, Mohammed T. ;
Pallett, Scott ;
Groppelli, Elisabetta ;
Boariu, Eugenia ;
Finardi, Nicole Falci ;
Wake, Rachel ;
Sofat, Nidhi ;
Biddle, Kathryn ;
Koushesh, Soraya ;
Dwyer-Hemmings, Louis ;
Cook, Richard ;
Ma, Julian K. -C. .
VACCINE, 2025, 56
[48]   COVID-19 infection and vaccination against SARS-CoV-2 in myasthenia gravis [J].
Peric, Stojan ;
Rankovic, Milos ;
Bozovic, Ivo ;
Radosavljevic, Vanja ;
Marjanovic, Ivan ;
Basta, Ivana ;
Lavrnic, Dragana .
ACTA NEUROLOGICA BELGICA, 2023, 123 (02) :529-536
[49]   Postinfectious Immunity After COVID-19 and Vaccination Against SARS-CoV-2 [J].
Krsak, Martin ;
Harry, Brian L. ;
Palmer, Brent E. ;
Franco-Paredes, Carlos .
VIRAL IMMUNOLOGY, 2021, 34 (08) :504-509
[50]   SARS-CoV-2 and the pandemic of COVID-19 [J].
Adil, Md Tanveer ;
Rahman, Rumana ;
Whitelaw, Douglas ;
Jain, Vigyan ;
Al-Taan, Omer ;
Rashid, Farhan ;
Munasinghe, Aruna ;
Jambulingam, Periyathambi .
POSTGRADUATE MEDICAL JOURNAL, 2021, 97 (1144) :110-116