Potential Druggability of Mesenchymal Stem/Stromal Cell-derived Exosomes

被引：2

作者：

Zhang, Fan ^{[1
]}

Zhang, Leisheng ^{[2
,3
]}

Yu, Hao ^{[4
]}

机构：

[1] Kunming Univ Sci & Technol, Fac Life Sci & Med, Kunming 650500, Peoples R China

[2] Shandong First Med Univ, Peoples Hosp Jinan 4, Sci & Technol Innovat Ctr, Dept Cardiol,Affiliated Hosp 3, Jinan 250031, Peoples R China

[3] Gansu Prov Hosp, Natl Hlth Commiss NHC, Key Lab Diag & Therapy Gastrointestinal Tumor, Lanzhou 730000, Peoples R China

[4] Nankai Univ, Sch Med, Postdoctoral Res Stn, Tianjin 300071, Peoples R China

来源：

CURRENT STEM CELL RESEARCH & THERAPY | 2024年 / 19卷 / 09期

关键词：

Exosomes; druggability; quality control; autocrine; sucrose; clinical application; NANOPARTICLE TRACKING ANALYSIS; CERVICAL STEM-CELLS; EXTRACELLULAR VESICLES; STROMAL CELLS; NEUROVASCULAR PLASTICITY; THERAPEUTIC-EFFICACY; FUNCTIONAL RECOVERY; ELECTRON-MICROSCOPY; PROTEOMIC ANALYSIS; CONDITIONED MEDIUM;

D O I：

10.2174/011574888X311270240319084835

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Exosomes secreted by mesenchymal stem/stromal cells (MSC-Exos) are advantageous candidate sources for novel acellular therapy. Despite the current standards of good manufacturing practice (GMP), the deficiency of suitable quality-control methods and the difficulties in large-scale preparation largely restrict the development of therapeutic products and their clinical applications worldwide. Herein, we mainly focus on three dominating issues commonly encountered in exosomal GMP, including issues upstream of the cell culture process, downstream of the purification process, exosomes quality control, and the drug properties of exosomes and their druggability from a corporate perspective. Collectively, in this review article, we put forward the issues of preparing clinical exosome drugs for the treatment of diverse diseases and provide new references for the clinical application of GMP-grade MSC-Exos.

引用

页码：1195 / 1209

页数：15

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