Roles of LncRNAs in the Pathogenesis of Pulmonary Hypertension

被引：0

作者：

Liu, Ting ^{[1
,2
]}

Xu, Shuanglan ^{[1
]}

Yang, Jiao ^{[3
]}

Xing, Xiqian ^{[1
]}

机构：

[1] Yunnan Univ, Dept Pulm & Crit Care Med, Affiliated Hosp, Kunming 650021, Yunnan, Peoples R China

[2] Kunming Med Univ, Grad Sch, Kunming 650500, Yunnan, Peoples R China

[3] Kunming Med Univ, Affiliated Hosp 1, Dept Pulm & Crit Care Med, Kunming 650032, Yunnan, Peoples R China

来源：

REVIEWS IN CARDIOVASCULAR MEDICINE | 2024年 / 25卷 / 06期

基金：

中国国家自然科学基金;

关键词：

pulmonary hypertension; long noncoding RNAs; pulmonary artery smooth muscle cells; pulmonary arterial endothelial cells; pulmonary adventitial fibroblasts; inflammatory and immune responses; right ventricle; vascular remodeling; LONG NONCODING RNA; MUSCLE-CELL PROLIFERATION; DOWN-REGULATION; UP-REGULATION; ENDOTHELIAL DYSFUNCTION; MESENCHYMAL TRANSITION; OXIDATIVE STRESS; CLASSIFICATION; INFLAMMATION; MIGRATION;

D O I：

10.31083/j.rcm2506217

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pulmonary hypertension (PH) is a persistently progressive, incurable, multifactorial associated fatal pulmonary vascular disease characterized by pulmonary vascular remodeling. Long noncoding RNAs (lncRNAs) are involved in regulating pathological processes such as pulmonary vasoconstriction, thickening, remodeling, and inflammatory cell infiltration in PH by acting on different cell types. Because of their differential expression in PH patients, as demonstrated by the observation that some lncRNAs are significantly upregulated while others are significantly downregulated in PH patients, lncRNAs are potentially useful biomarkers for assessing disease progression and diagnosis or prognosis in PH patients. This article provides an overview of the different mechanisms by which lncRNAs are involved in the pathogenesis of PH.

引用

页数：20