Unraveling the intricacies of host-pathogen interaction through single-cell genomics

被引:2
作者
Gioacchino, Emanuele [1 ]
Vandelannoote, Koen [2 ]
Ruberto, Anthony A. [3 ,4 ]
Popovici, Jean [5 ,6 ]
Cantaert, Tineke [1 ]
机构
[1] Inst Pasteur Cambodge, Pasteur Network, Immunol Unit, Phnom Penh, Cambodia
[2] Pasteur Network, Inst Pasteur Cambodge, Bacterial Phylogen Grp, Phnom Penh, Cambodia
[3] Univ Georgia, Ctr Trop & Emerging Global Dis, Athens, GA USA
[4] Univ Georgia, Inst Bioinformat, Athens, GA 30605 USA
[5] Inst Pasteur Cambodge, Malaria Res Unit, Pasteur Network, Phnom Penh, Cambodia
[6] Inst Pasteur, Infect Dis Epidemiol & Analyt, Paris, France
关键词
Infectious disease biology; Host-pathogen interaction; Single-cell genomics; Single-cell RNA sequencing; RNA-SEQ; HETEROGENEITY;
D O I
10.1016/j.micinf.2024.105313
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Single-cell genomics provide researchers with tools to assess host-pathogen interactions at a resolution previously inaccessible. Transcriptome analysis, epigenome analysis, and immune profiling techniques allow for a better comprehension of the heterogeneity underlying both the host response and infectious agents. Here, we highlight technological advancements and data analysis workflows that increase our understanding of host-pathogen interactions at the single-cell level. We review various studies that have used these tools to better understand host-pathogen dynamics in a variety of infectious disease contexts, including viral, bacterial, and parasitic diseases. We conclude by discussing how single-cell genomics can advance our understanding of host-pathogen interactions. (c) 2024 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页数:9
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