Voluntary exercise suppresses inflammation and improves insulin resistance in the arcuate nucleus and ventral tegmental area in mice on a high-fat diet

被引：1

作者：

Sasaki, Tomoyuki ^{[1
]}

Sugiyama, Mariko ^{[1
]}

Kuno, Mitsuhiro ^{[1
]}

Miyata, Takashi ^{[1
]}

Kobayashi, Tomoko ^{[1
]}

Yasuda, Yoshinori ^{[1
]}

Onoue, Takeshi ^{[1
]}

Takagi, Hiroshi ^{[1
,2
]}

Hagiwara, Daisuke ^{[1
]}

Iwama, Shintaro ^{[1
]}

Suga, Hidetaka ^{[1
]}

Banno, Ryoichi ^{[1
,3
]}

Arima, Hiroshi ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Endocrinol & Diabet, Nagoya 4668550, Japan

[2] Nagoya City Univ, Grad Sch Med Sci, Dept Gastroenterol & Metab, Nagoya 4678602, Japan

[3] Nagoya Univ, Res Ctr Hlth Phys Fitness & Sports, Nagoya, 4648601, Japan

来源：

PHYSIOLOGY & BEHAVIOR | 2024年 / 287卷

关键词：

Arcuate nucleus; Inflammation; Insulin resistance; Obesity; Ventral tegmental area; Voluntary exercise; BETA/NF-KAPPA-B; HYPOTHALAMIC INFLAMMATION; INDUCED OBESITY; SENSITIVITY; EXPRESSION; GLUCOSE; REWARD; FOOD;

D O I：

10.1016/j.physbeh.2024.114703

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

A high-fat diet (HFD) causes inflammation with an increase in microglial activity in the hypothalamic arcuate nucleus (ARC) and ventral tegmental area (VTA), resulting in insulin resistance in both regions. This leads to a deterioration in glucose and energy metabolism. The effect of voluntary exercise on HFD-induced inflammation in the central nervous system (CNS) remains unclear. To clarify the effects of voluntary exercise on the CNS, 8week-old male C57BL6 mice were fed a chow diet (CHD) or HFD for 4 weeks; each group was further divided into running exercise (EX+) on a wheel and no exercise (EX-) groups. The expression of the inflammatory cytokine, tumor necrosis factor alpha (TNF alpha), in the ARC and VTA was significantly increased in the HFD/EX- group, with an increase of microglial activity noted, compared to the CHD/EX- group. The expression of TNF alpha was significantly suppressed, with a decrease of microglial activity, in the HFD/EX+ compared to HFD/EX- group. Insulin resistance in the ARC and VTA was improved with the suppression of TNF alpha expression. The HFD/EX- group showed significant weight gain and impaired glucose metabolism compared to the CHD/EX- group. The HFD/ EX+ group showed an improvement in glucose and energy metabolism compared to the HFD/EX- group. In addition, voluntary wheel running suppressed HFD-induced inflammation in the ARC, with a decrease in microglial activity observed independently of weight changes. Our data suggest that voluntary exercise prevents obesity and improves glucose metabolism by suppressing inflammation in the ARC and VTA under HFD conditions.

引用

页数：11

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[29] Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet [J].

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