The altered resting-state functional connectivity of thalamic subregions in patients with globus pharyngeus

被引:0
作者
Hu, Yuanyuan [1 ,2 ]
Zhao, Jingjie [3 ]
Jin, Yuening [1 ,2 ]
Du, Yi [3 ]
Zhao, Qian [3 ]
Xu, Shuai [3 ]
Li, Li [3 ]
Zhou, Yuan [1 ,2 ,4 ]
机构
[1] Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, 16 Lincui Rd, Beijing 100101, Peoples R China
[2] Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
[3] Capital Med Univ, Beijing Friendship Hosp, Dept Tradit Chinese Med, Beijing 100050, Peoples R China
[4] Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing Key Lab Mental Disorders, Beijing, Peoples R China
基金
中国国家自然科学基金;
关键词
Globus Pharyngeus; Resting-state functional magnetic resonance imaging; Functional connectivity; Thalamus; CINGULATE CORTEX; ANXIETY DISORDER; PAIN; DEPRESSION; ETIOLOGY; CYTOARCHITECTURE; SEVERITY; VALIDITY;
D O I
10.1007/s11682-024-00940-4
中图分类号
R445 [影像诊断学];
学科分类号
100207 ;
摘要
Globus Pharyngeus (GP) is a somatic symptom that accompanies mood distress. Although the etiology of GP remains unclear, its specific symptom of a false lump sensation in the throat without physical obstruction raises the possibility of alterations in brain networks responsible for somatosensory and emotion processing in patients with GP. To address this possibility, we investigated resting-state functional connectivity (rsFC) in 31 patients with GP and 24 healthy individuals using resting-state functional magnetic resonance imaging. Considering its significance in somatosensory and emotional functions, we focused on rsFC in the subregions of the thalamus. We found significantly decreased rsFC between the right caudal temporal thalamus (rcTtha) and the midcingulate cortex (MCC) as well as significantly decreased rsFC between the right rostral temporal thalamus (rrTtha) and the left cerebellum in the patients with GP. Additionally, within the patient group, the abnormalities in rsFC between the rcTtha and the MCC were correlated with the severity of somatization symptoms but not with depression and anxiety. These findings suggest alterations in the rsFC of thalamic subregions in patients with GP, shedding light on the pathogenesis of GP and potentially leading to improved diagnosis and treatment approaches for the condition.
引用
收藏
页码:23 / 31
页数:9
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