Anti-IgLON5 Disease Showing an Improvement in Dysautonomia, Including Vocal Cord Palsy, via Combined Immunotherapy

被引：3

作者：

Sato, Daisuke ^{[1
]}

Sato, Hiroyasu ^{[1
]}

Kondo, Toshiyuki ^{[1
]}

Igari, Ryosuke ^{[1
]}

Iseki, Chifumi ^{[1
]}

Kawahara, Hikaru ^{[1
]}

Amano, Shintaro ^{[2
]}

Ono, Yoya ^{[3
]}

Kimura, Akio ^{[3
]}

Shimohata, Takayoshi ^{[3
]}

Ohta, Yasuyuki ^{[1
]}

机构：

[1] Yamagata Univ, Dept Internal Med 3, Div Neurol & Clin Neurosci, Sch Med, Yamagata, Japan

[2] Yamagata Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Yamagata, Japan

[3] Gifu Univ, Dept Neurol, Grad Sch Med, Gifu, Japan

来源：

INTERNAL MEDICINE | 2024年 / 63卷 / 15期

关键词：

anti-IgLON5; disease; dysautonomia; vocal cord palsy; combined immunotherapy;

D O I：

10.2169/internalmedicine.2865-23

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Anti-IgLON5 disease shows various neurological manifestations, of which dysautonomia is one of the major symptoms and is rarely improved by immunotherapy. We herein report a patient with anti-IgLON5 disease who showed several autonomic failures, including vocal cord palsy for four months. The patient presented with cognitive impairments, bulbar symptoms accompanied by myorhythmia in the pharynx and tongue, cerebellar ataxia with tremor, motor neuron symptoms in the limbs, gastrointestinal dysfunction, orthostatic hypotension, non-rapid eye movement sleep disorder on polysomnography, and severe vocal cord palsy. Combined immunotherapy improved his symptoms, including vocal cord palsy, suggesting that combined immunotherapy might improve dysautonomia in anti-IgLON5 disease.

引用

页码：2187 / 2191

页数：5

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