Phenolic profiling by UPLC-MS/MS and hepatoprotective activity of Cardiospermum halicacabum against CCl4 induced liver injury in Wistar rats

被引：26
|
作者：
Jeyadevi, R. [1 ]
Sivasudha, T. [1 ]
Rameshkumar, A. [1 ]
Harnly, James M. [2 ]
Lin, Long-Ze [2 ]
机构：
[1] Bharathidasan Univ, Dept Environm Biotechnol, Tiruchirappalli 620024, Tamil Nadu, India
[2] USDA, Food Composit & Methods Dev Lab, Beltsville Human Nutr Res Ctr, Beltsville, MD 20705 USA
来源：
JOURNAL OF FUNCTIONAL FOODS | 2013年 / 5卷 / 01期
关键词：
Cardiospermum halicacabum; UPLC-MS/MS analysis; Phenolic profile; Ames test; Carbon tetrachloride; Hepatoprotectivity; ANTIOXIDANT ACTIVITY; SUPEROXIDE-DISMUTASE;
D O I：
10.1016/j.jff.2012.10.019
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The hepatoprotective potential of ethanolic extract of Cardiospermum halicacabum (ECH) was evaluated in Wistar rats having liver injury induced by CCl4. The free radical scavenging activity of ECH was evaluated by ABTS and DPPH assay. Phenolic compounds like luteolin 7-o-glucoronide, apigenin 7-o-glucoronide and chrysoerisol 7-o-glucoronide were identified in ECH by UPLC-MS/MSn analysis. On the other hand, the anti mutagenic effect of ECH was examined using tester strain Salmonella typhimurium TA100 with and without S9 extract. CCl4 administered Wistar rats exhibited alteration in various biochemical parameters which were significantly (P <= 0.05) restored toward normal level by the therapy of ECH. ECH significantly (P <= 0.05) reduced LPO level in the liver tissue. Treatment with ECH showed curative effect on histopathological alterations and DNA damage in CCl4 administered rats in a dose dependent manner. Silymarin, a routine hepatoprotective drug was used as reference standard. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：289 / 298
页数：10
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