Neuropeptide Network of Polycystic Ovary Syndrome - A Review

被引:0
作者
Jayamurali, Dheepthi [1 ]
Ravishankar, Nivetha [1 ]
Manoharan, Nivedita [1 ]
Parasuraman, Rajeshwari [1 ]
Jayashankar, Sri Kameshwaran [1 ]
Govindarajulu, Sathya Narayanan [1 ]
机构
[1] Univ Madras, Dr ALM PG Inst Basic Med Sci, Dept Physiol, Chennai 600113, India
关键词
Neuropeptides; polycystic ovary syndrome; kisspeptin; neurokinin B; dynorphin A; nesfatin; neudesin; neuropeptide Y; beta-endorphin; phoenixin; leptin; ghrelin; orexin; PLASMA BETA-ENDORPHIN; HYPOGONADOTROPIC HYPOGONADISM; LUTEINIZING-HORMONE; OBESE-PATIENTS; GHRELIN LEVELS; RAT MODEL; NESFATIN-1; WOMEN; HYPOTHALAMUS; METABOLISM;
D O I
10.2174/0109298665309949240822105900
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background: Polycystic Ovary Syndrome (PCOS), the ubiquitous reproductive disorder, has been documented as highly prevalent (6-9%) in India. 10% of women globally are predicted to have the disease. The highly mutable endocrinopathy, with differential clinical criteria for each diagnosis of PCOS, can mask the severity of the syndrome by influencing the incidence and occurrence of PCOS. Area Covered: When there is a solid theoretical hypothesis between the neuroendocrine origin and ovarian origin of PCOS, recent evidence supports the neuroendocrine derivation of the pathology. It is considered of neuroendocrine basis - as it controls the ovarian axis and acts as a delicate target because it possesses receptors for various gonadal hormones, neurotransmitters & neuropeptides. Can these neuroendocrine alterations, variations in central brain circuits, and neuropeptide dysregulation be the tie that would link the pathophysiology of the disorder, the occurrence of all the 1 & ring; and 2(degrees )symptoms like polycystic ovaries, hyperandrogenism, obesity, insulin resistance, etc., in PCOS? Conclusion: This review anticipates providing a comprehensive overview of how neuropeptides such as Kisspeptin, Neurokinin B, Dynorphin A, beta-Endorphin, Nesfatin, Neuropeptide Y, Phoenixin, Leptin, Ghrelin, Orexin, and Neudesin influence PCOS, the understanding of which may help to establish potential drug candidates against precise targets in these central circuits.
引用
收藏
页码:667 / 680
页数:14
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