Induced pluripotent stem cell therapies in heart failure treatment: a meta-analysis and systematic review

被引：0
作者：
Le, Duy Cao Phuong [1 ,3 ]
Bui, Hoa The [1 ]
Vu, Yen Thi Hai [2 ]
Vo, Quan Duy [1 ,3 ,4 ]
机构：
[1] Nguyen Tri Phuong Hosp, Dept Cardiovasc Intervent, Ho Chi Minh City 700000, Vietnam
[2] Thai Binh Univ Med, Fac Med, Thai Binh 61000, Vietnam
[3] Nguyen Tat Thanh Univ, Fac Med, Ho Chi Minh City 700000, Vietnam
[4] Okayama Univ, Cardiovasc Med Dept, Okayama 7000000, Japan
来源：
REGENERATIVE MEDICINE | 2024年 / 19卷 / 9-10期
关键词：
heart failure; induced pluripotent stem cells; meta-analysis; outcomes; treatment; ACUTE MYOCARDIAL-INFARCTION; CARDIAC-MUSCLE; REPAIR; TRANSPLANTATION; EFFICACY; DIFFERENTIATION; CARDIOMYOCYTES; REGENERATION; ENGRAFTMENT; SKELETAL;
D O I：
10.1080/17460751.2024.2393558
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Background: Heart failure (HF) causes over 266,400 deaths annually. Despite treatment advancements, HF mortality remains high. Induced pluripotent stem cells (iPSCs) offer promising new options. This review assesses iPSC-based treatments for HF. Method: the review included studies from PubMed, ScienceDirect and Web of Science. Results: Analysis of 25 studies with 553 animals showed a baseline ejection fraction (EF) of 39.2 +/- 8.9%. iPSC treatment significantly improved EF (MD = 8.6, p < 0.001) and fractional shortening (MD = 6.38, p < 0.001), and reduced ventricular remodeling without increasing arrhythmia risk. Conclusion: iPSC-based therapy improves heart function and reduces ventricular volumes in HF animal models, aligning with promising early clinical trial outcomes.
引用
收藏
页码：497 / 509
页数：13
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