Induced pluripotent stem cell therapies in heart failure treatment: a meta-analysis and systematic review

被引：0
作者：
Le, Duy Cao Phuong [1 ,3 ]
Bui, Hoa The [1 ]
Vu, Yen Thi Hai [2 ]
Vo, Quan Duy [1 ,3 ,4 ]
机构：
[1] Nguyen Tri Phuong Hosp, Dept Cardiovasc Intervent, Ho Chi Minh City 700000, Vietnam
[2] Thai Binh Univ Med, Fac Med, Thai Binh 61000, Vietnam
[3] Nguyen Tat Thanh Univ, Fac Med, Ho Chi Minh City 700000, Vietnam
[4] Okayama Univ, Cardiovasc Med Dept, Okayama 7000000, Japan
来源：
REGENERATIVE MEDICINE | 2024年 / 19卷 / 9-10期
关键词：
heart failure; induced pluripotent stem cells; meta-analysis; outcomes; treatment; ACUTE MYOCARDIAL-INFARCTION; CARDIAC-MUSCLE; REPAIR; TRANSPLANTATION; EFFICACY; DIFFERENTIATION; CARDIOMYOCYTES; REGENERATION; ENGRAFTMENT; SKELETAL;
D O I：
10.1080/17460751.2024.2393558
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Background: Heart failure (HF) causes over 266,400 deaths annually. Despite treatment advancements, HF mortality remains high. Induced pluripotent stem cells (iPSCs) offer promising new options. This review assesses iPSC-based treatments for HF. Method: the review included studies from PubMed, ScienceDirect and Web of Science. Results: Analysis of 25 studies with 553 animals showed a baseline ejection fraction (EF) of 39.2 +/- 8.9%. iPSC treatment significantly improved EF (MD = 8.6, p < 0.001) and fractional shortening (MD = 6.38, p < 0.001), and reduced ventricular remodeling without increasing arrhythmia risk. Conclusion: iPSC-based therapy improves heart function and reduces ventricular volumes in HF animal models, aligning with promising early clinical trial outcomes.
引用
收藏
页码：497 / 509
页数：13
相关论文
共 50 条
  • [21] Induced pluripotent stem cells in rat models of Parkinson's disease: A systematic review and meta-analysis
    Zhang, Yunxia
    Ge, Meiling
    Hao, Qiukui
    Dong, Birong
    BIOMEDICAL REPORTS, 2018, 8 (03) : 289 - 296
  • [22] Vasopressin receptor antagonists for the treatment of heart failure: a systematic review and meta-analysis of randomized controlled trials
    Nistor, Ionut
    Bararu, Iris
    Apavaloaie, Maria-Cristina
    Voroneanu, Luminita
    Donciu, Mihaela-Dora
    Kanbay, Mehmet
    Nagler, Evi V.
    Covic, Adrian
    INTERNATIONAL UROLOGY AND NEPHROLOGY, 2015, 47 (02) : 335 - 344
  • [23] The Effect of Advance Care Planning on Heart Failure: a Systematic Review and Meta-analysis
    Markus Schichtel
    Bee Wee
    Rafael Perera
    Igho Onakpoya
    Journal of General Internal Medicine, 2020, 35 : 874 - 884
  • [24] Natriuretic peptide-guided treatment for heart failure: a systematic review and meta-analysis
    McLellan, Julie
    Bankhead, Clare R.
    Oke, Jason L.
    Hobbs, F. D. Richard
    Taylor, Clare J.
    Perera, Rafael
    BMJ EVIDENCE-BASED MEDICINE, 2020, 25 (01) : 33 - 37
  • [25] Gender differences in the prevalence of frailty in heart failure: A systematic review and meta-analysis
    Davis, Mary Roberts
    Lee, Christopher S.
    Corcoran, Amy
    Gupta, Nandita
    Uchmanowicz, Izabella
    Denfeld, Quin E.
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2021, 333 : 133 - 140
  • [26] Tolvaptan in reversing worsening acute heart failure: A systematic review and meta-analysis
    Wang, Lili
    Zhang, Qianhui
    Liu, Meixia
    Chen, Shuxia
    Han, Shuang
    Li, Jing
    Du, Rongpin
    JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2019, 47 (11) : 5414 - 5425
  • [27] Heart failure in Nigeria: protocol for a systematic review and meta-analysis
    Ogah, Okechukwu S.
    Kushimo, Oyewole A.
    Adebiyi, Adewole
    Onyema, Chuka T.
    Uchenna, Onubogu C.
    Adebayo, Bosede E.
    Agaja, Oyinkansola T.
    Orimolade, Olanike A.
    Durodola, Amina
    Makinde, Isa A.
    Akinyemi, Rufus O.
    Adedeji, Waheed A.
    Adekanmi, Ademola J.
    Akinyemi, Joshua O.
    Adedokun, Babatunde
    AFRICAN HEALTH SCIENCES, 2023, 23 (02) : 530 - 536
  • [28] The Effect of Advance Care Planning on Heart Failure: a Systematic Review and Meta-analysis
    Schichtel, Markus
    Wee, Bee
    Perera, Rafael
    Onakpoya, Igho
    JOURNAL OF GENERAL INTERNAL MEDICINE, 2020, 35 (03) : 874 - 884
  • [29] The evidence for pharmacist care in outpatients with heart failure: a systematic review and meta-analysis
    Schumacher, Pia M.
    Becker, Nicolas
    Tsuyuki, Ross T.
    Griese-Mammen, Nina
    Koshman, Sheri L.
    McDonald, Michael A.
    Bouvy, Marcel
    Rutten, Frans H.
    Laufs, Ulrich
    Bohm, Michael
    Schulz, Martin
    ESC HEART FAILURE, 2021, 8 (05): : 3566 - 3576
  • [30] Safety and effectiveness of stem cell therapies in early-phase clinical trials in stroke: a systematic review and meta-analysis
    Nagpal, Anjali
    Choy, Fong Chan
    Howell, Stuart
    Hillier, Susan
    Chan, Fiona
    Hamilton-Bruce, Monica A.
    Koblar, Simon A.
    STEM CELL RESEARCH & THERAPY, 2017, 8
12345