Quantitative computed tomography-based approaches for noninvasive diagnosis of portal hypertension in patients with cirrhosis

Noninvasive diagnosis of portal hypertension in patients with cirrhosis can be achieved using different methods, including laboratory tests and imaging. The Baveno VII consensus suggested that liver stiffness measurements and platelet counts were sufficient for assessing the presence of clinically significant portal hypertension. However, computed tomography (CT) is frequently performed in patients with cirrhosis, and numerous studies have established the possibility of an opportunistic noninvasive diagnosis of portal hypertension using CT. These studies have utilized radiomics, volumetric changes in the liver and spleen, quantitative assessment of liver surface nodularity, and more advanced techniques based on computational fluid dynamics. This review summarizes the main original studies related to the quantitative CT-based noninvasive diagnosis of portal hypertension.