TTYH3 Promotes Cervical Cancer Progression by Activating the Wnt/β-Catenin Signaling Pathway

被引：1

作者：

Huang, Xiuyan ^{[1
]}

Li, Qing ^{[1
]}

Zheng, Xiaoxia ^{[1
]}

Jiang, Chen ^{[1
]}

机构：

[1] Jinan Matern & Child Care Hosp, Dept Gynaecol, 2 Jianguo Xiao Jingsan Rd Jinan, Jinan 250001, Shandong, Peoples R China

来源：

CANCER INVESTIGATION | 2024年 / 42卷 / 08期

关键词：

TTYH3; Wnt/beta-catenin signaling; cervical cancer; TWEETY; HOMOLOG; GENE;

D O I：

10.1080/07357907.2024.2395014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The role of tweety homolog 3 (TTYH3) has been studied in several cancers, including hepatocellular carcinoma, cholangiocarcinoma, and gastric cancer. The results showed that TTYH3 is highly expression in cervical cancer tissues and cells and high TTYH3 expression correlates with poor prognosis in patients with cervical cancer. TTYH3 markedly reduced the apoptosis rate and promoted proliferation, migration, and invasion. Silencing of TTYH3 has been shown to have an inhibitory effect on cervical cancer progression. Moreover, TTYH3 enhanced EMT and activated Wnt/beta-catenin signaling. Furthermore, TTYH3 knockdown inhibited the tumor growth in vivo. In conclusion, TTYH3 promoted cervical cancer progression by activating the Wnt/beta-catenin signaling.

引用

页码：726 / 739

页数：14

共 50 条

[1] LncRNA CASC11 promotes the cervical cancer progression by activating Wnt/beta-catenin signaling pathway
Wenchan Hsu
Lifen Liu
Xin Chen
Ying Zhang
Weipei Zhu
Biological Research, 52
[2] LncRNA CASC11 promotes the cervical cancer progression by activating Wnt/beta-catenin signaling pathway
Hsu, Wenchan
Liu, Lifen
Chen, Xin
Zhang, Ying
Zhu, Weipei
BIOLOGICAL RESEARCH, 2019, 52 (1) : 33
[3] Upregulation of TTYH3 promotes epithelial-to-mesenchymal transition through Wnt/β-catenin signaling and inhibits apoptosis in cholangiocarcinoma
Xue, Weijie
Dong, Bingzi
Zhao, Yanjie
Wang, Yixiu
Yang, Chenyu
Xie, Yuwei
Niu, Zhaojian
Zhu, Chengzhan
CELLULAR ONCOLOGY, 2021, 44 (06) : 1351 - 1361
[4] Upregulation of TTYH3 promotes epithelial-to-mesenchymal transition through Wnt/β-catenin signaling and inhibits apoptosis in cholangiocarcinoma
Weijie Xue
Bingzi Dong
Yanjie Zhao
Yixiu Wang
Chenyu Yang
Yuwei Xie
Zhaojian Niu
Chengzhan Zhu
Cellular Oncology, 2021, 44 : 1351 - 1361
[5] FOXH1 promotes lung cancer progression by activating the Wnt/β-catenin signaling pathway
Jun Zhang
Xian Zhang
Shasha Yang
Yanqiu Bao
Dongyuan Xu
Lan Liu
Cancer Cell International, 21
[6] FOXH1 promotes lung cancer progression by activating the Wnt/β-catenin signaling pathway
Zhang, Jun
Zhang, Xian
Yang, Shasha
Bao, Yanqiu
Xu, Dongyuan
Liu, Lan
CANCER CELL INTERNATIONAL, 2021, 21 (01)
[7] Biliverdin Reductase A (BLVRA) Promotes Colorectal Cancer Cell Progression by Activating the Wnt/β-Catenin Signaling Pathway
Mao, Haiyan
Xu, Yuan
Zhang, Zhengrong
Sun, Guozhuang
Wang, Zhu
Qiao, Dawei
Yin, Xudong
Liu, Siping
Bo, Ping
CANCER MANAGEMENT AND RESEARCH, 2020, 12 : 2697 - 2709
[8] PAK6 promotes cervical cancer progression through activation of the Wnt/β-catenin signaling pathway
Yang, Qin
Zhao, Yingchao
Chen, Yeshan
Chang, Yu
Huang, Ai
Xu, Tie
Li, Guiling
Wu, Gang
ONCOLOGY LETTERS, 2020, 20 (03) : 2387 - 2395
[9] KIF18B promotes tumor progression through activating the Wnt/β-catenin pathway in cervical cancer
Wu, Yaqin
Wang, Anpeng
Zhu, Biqing
Huang, Jian
Lu, Emei
Xu, Hanzi
Xia, Wenjie
Dong, Gaochao
Jiang, Feng
Xu, Lin
ONCOTARGETS AND THERAPY, 2018, 11 : 1707 - 1720
[10] Effect of TTYH3 on cholangiocarcinoma invasion, metastasis and lymph node metastasis through Wnt/β-catenin pathway.
Xie, Yuwei
Wu, Shengze
Du, Fangqian
Gao, Ruiqian
Wu, Tingting
Jin, Chen
Cao, Jingyu
Zhu, Chengzhan
JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (23_SUPPL) : 57 - 57

← 1 2 3 4 5 →