Value of the triglyceride-glucose index and related parameters in heart failure patients

被引：2
作者：
Fang, Yunteng [1 ,2 ,3 ]
Shen, Jiayi [2 ,3 ]
Lyu, Lingchun [1 ,2 ,3 ]
机构：
[1] Zhejiang Univ, Lishui Hosp, Sch Med, Hangzhou, Peoples R China
[2] Wenzhou Med Univ, Lishui Cent Hosp, Lishui, Peoples R China
[3] Wenzhou Med Univ, Affiliated Hosp 5, Lishui, Peoples R China
来源：
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2024年 / 11卷
关键词：
TyG index; heart failure; obesity paradox; SGLT-2; inhibitors; HOMA-IR; GLP-1 RECEPTOR AGONISTS; REDUCED EJECTION FRACTION; SGLT2; INHIBITORS; NT-PROBNP; METAANALYSIS; OUTCOMES; EMPAGLIFLOZIN;
D O I：
10.3389/fcvm.2024.1397907
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The triglyceride-glucose (TyG) index, proven to be a crucial insulin resistance biomarker (better than the Homeostasis Model Assessment for Insulin Resistance), is simple and non-invasive. Recently, indisputable evidence has shown that the TyG index is strongly associated with cardiovascular disease [CVD, including atherosclerosis, heart failure (HF), and hypertension] prognosis and mortality. Nevertheless, the value of the TyG index in HF patients treated with sodium-glucose cotransporter 2 inhibitors (SGLT2is) has not been systematically evaluated. Therefore, in this review, we summarized the value of the TyG index and its related parameters as markers of CVD, especially HF. Furthermore, we addressed the use of SGLT2is and GLP-1 receptor antagonists in HF patients. Finally, we summarized the mechanism of the "obesity paradox."
引用
收藏
页数：10
相关论文
共 96 条
[51]   Insulin resistance drives cognitive impairment in hypertensive pre-diabetic frail elders: the CENTENNIAL study [J].
Mone, Pasquale ;
De Gennaro, Stefano ;
Moriello, Divina ;
Frullone, Salvatore ;
D'Amelio, Rosa ;
Ferrante, Mario Nicola Vittorio ;
Marro, Anna ;
Santulli, Gaetano .
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, 2023, 30 (12) :1283-1288
[52]   Influence of NT-proBNP on Efficacy of Dapagliflozin in Heart Failure With Mildly Reduced or Preserved Ejection Fraction [J].
Myhre, Peder L. ;
Vaduganathan, Muthiah ;
Claggett, Brian L. ;
Miao, Zi Michael ;
Jhund, Pardeep S. ;
de Boer, Rudolf A. ;
Hernandez, Adrian F. ;
Inzucchi, Silvio E. ;
Kosiborod, Mikhail N. ;
Lam, Carolyn S. P. ;
Martinez, Felipe ;
Shah, Sanjiv J. ;
Desai, Akshay S. ;
Lindholm, Daniel ;
Petersson, Magnus ;
Langkilde, Anna Maria ;
McMurray, John J. V. ;
Solomon, Scott D. .
JACC-HEART FAILURE, 2022, 10 (12) :902-913
[53]   High percent body fat mass predicts lower risk of cardiac events in patients with heart failure: an explanation of the obesity paradox [J].
Ohori, Katsuhiko ;
Yano, Toshiyuki ;
Katano, Satoshi ;
Kouzu, Hidemichi ;
Honma, Suguru ;
Shimomura, Kanako ;
Inoue, Takuya ;
Takamura, Yuhei ;
Nagaoka, Ryohei ;
Koyama, Masayuki ;
Nagano, Nobutaka ;
Fujito, Takefumi ;
Nishikawa, Ryo ;
Ishigo, Tomoyuki ;
Watanabe, Ayako ;
Hashimoto, Akiyoshi ;
Miura, Tetsuji .
BMC GERIATRICS, 2021, 21 (01)
[54]   Association between insulin resistance and the development of cardiovascular disease [J].
Ormazabal, Valeska ;
Nair, Soumyalekshmi ;
Elfeky, Omar ;
Aguayo, Claudio ;
Salomon, Carlos ;
Zuniga, Felipe A. .
CARDIOVASCULAR DIABETOLOGY, 2018, 17
[55]   Admission triglyceride-glucose index is predictor of long-term mortality and appropriate implantable cardiac defibrillator therapy in patients with heart failure [J].
Ozcan, Kazim S. ;
Hayiroglu, Mert, I ;
Cinar, Tufan .
BIOMARKERS IN MEDICINE, 2023, 17 (10) :487-496
[56]   Effect of Empagliflozin on Worsening Heart Failure Events in Patients With Heart Failure and Preserved Ejection Fraction EMPEROR-Preserved Trial [J].
Packer, Milton ;
Butler, Javed ;
Zannad, Faiez ;
Filippatos, Gerasimos ;
Ferreira, Joao Pedro ;
Pocock, Stuart J. ;
Carson, Peter ;
Anand, Inder ;
Doehner, Wolfram ;
Haass, Markus ;
Komajda, Michel ;
Miller, Alan ;
Pehrson, Steen ;
Teerlink, John R. ;
Schnaidt, Sven ;
Zeller, Cordula ;
Schnee, Janet M. ;
Anker, Stefan D. .
CIRCULATION, 2021, 144 (16) :1284-1294
[57]   The obesity paradox in heart failure patients with preserved versus reduced ejection fraction: a meta-analysis of individual patient data [J].
Padwal, R. ;
McAlister, F. A. ;
McMurray, J. J. V. ;
Cowie, M. R. ;
Rich, M. ;
Pocock, S. ;
Swedberg, K. ;
Maggioni, A. ;
Gamble, G. ;
Ariti, C. ;
Earle, N. ;
Whalley, G. ;
Poppe, K. K. ;
Doughty, R. N. ;
Bayes-Genis, A. .
INTERNATIONAL JOURNAL OF OBESITY, 2014, 38 (08) :1110-1114
[58]   Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials [J].
Palmer, Suetonia C. ;
Tendal, Britta ;
Mustafa, Reem A. ;
Vandvik, Per Olav ;
Li, Sheyu ;
Hao, Qiukui ;
Tunnicliffe, David ;
Ruospo, Marinella ;
Natale, Patrizia ;
Saglimbene, Valeria ;
Nicolucci, Antonio ;
Johnson, David W. ;
Tonelli, Marcello ;
Rossi, Maria Chiara ;
Badve, Sunil, V ;
Cho, Yeoungjee ;
Nadeau-Fredette, Annie-Claire ;
Burke, Michael ;
Faruque, Labib, I ;
Lloyd, Anita ;
Ahmad, Nasreen ;
Liu, Yuanchen ;
Tiv, Sophanny ;
Millard, Tanya ;
Gagliardi, Lucia ;
Kolanu, Nithin ;
Barmanray, Rahul D. ;
McMorrow, Rita ;
Cortez, Ana Karina Raygoza ;
White, Heath ;
Chen, Xiangyang ;
Zhou, Xu ;
Liu, Jiali ;
Rodriguez, Andrea Flores ;
Gonzalez-Colmenero, Alejandro Diaz ;
Wang, Yang ;
Li, Ling ;
Sutanto, Surya ;
Solis, Ricardo Cesar ;
Gonzalez-Colmenero, Fernando Diaz ;
Rodriguez-Gutierrez, Rene ;
Walsh, Michael ;
Guyatt, Gordon ;
Strippoli, Giovanni F. M. .
BMJ-BRITISH MEDICAL JOURNAL, 2021, 372
[59]   Triglyceride-glucose index and cervical vascular function: outpatient-based cohort study [J].
Pan, Xiaoyu ;
Yue, Lin ;
Ren, Lin ;
Ban, Jiangli ;
Chen, Shuchun .
BMC ENDOCRINE DISORDERS, 2023, 23 (01)
[60]   The triglyceride-glucose index is a more powerful surrogate marker for predicting the prevalence and incidence of type 2 diabetes mellitus than the homeostatic model assessment of insulin resistance [J].
Park, Hye Min ;
Lee, Hye Sun ;
Lee, Yong-Jae ;
Lee, Jun-Hyuk .
DIABETES RESEARCH AND CLINICAL PRACTICE, 2021, 180
12345678910