Value of the triglyceride-glucose index and related parameters in heart failure patients

被引：2

作者：

Fang, Yunteng ^{[1
,2
,3
]}

Shen, Jiayi ^{[2
,3
]}

Lyu, Lingchun ^{[1
,2
,3
]}

机构：

[1] Zhejiang Univ, Lishui Hosp, Sch Med, Hangzhou, Peoples R China

[2] Wenzhou Med Univ, Lishui Cent Hosp, Lishui, Peoples R China

[3] Wenzhou Med Univ, Affiliated Hosp 5, Lishui, Peoples R China

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2024年 / 11卷

关键词：

TyG index; heart failure; obesity paradox; SGLT-2; inhibitors; HOMA-IR; GLP-1 RECEPTOR AGONISTS; REDUCED EJECTION FRACTION; SGLT2; INHIBITORS; NT-PROBNP; METAANALYSIS; OUTCOMES; EMPAGLIFLOZIN;

D O I：

10.3389/fcvm.2024.1397907

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The triglyceride-glucose (TyG) index, proven to be a crucial insulin resistance biomarker (better than the Homeostasis Model Assessment for Insulin Resistance), is simple and non-invasive. Recently, indisputable evidence has shown that the TyG index is strongly associated with cardiovascular disease [CVD, including atherosclerosis, heart failure (HF), and hypertension] prognosis and mortality. Nevertheless, the value of the TyG index in HF patients treated with sodium-glucose cotransporter 2 inhibitors (SGLT2is) has not been systematically evaluated. Therefore, in this review, we summarized the value of the TyG index and its related parameters as markers of CVD, especially HF. Furthermore, we addressed the use of SGLT2is and GLP-1 receptor antagonists in HF patients. Finally, we summarized the mechanism of the "obesity paradox."

引用

页数：10

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