Deciphering Fc-effector functions against SARS-CoV-2

被引：5

作者：

Beaudoin-Bussieres, Guillaume ^{[1
,2
]}

Finzi, Andres ^{[1
,2
]}

机构：

[1] Ctr Rech CHUM, Montreal, PQ H2X 0A9, Canada

[2] Univ Montreal, Dept Microbiol Infectiol & Immunol, Montreal, PQ H2X 0A9, Canada

来源：

TRENDS IN MICROBIOLOGY | 2024年 / 32卷 / 08期

基金：

加拿大健康研究院;

关键词：

NEUTRALIZING ANTIBODIES; SPIKE; REVEALS; BINDING; PLASMA;

D O I：

10.1016/j.tim.2024.01.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Major efforts were deployed to study the antibody response against SARSCoV-2. Antibodies neutralizing SARS-CoV-2 have been extensively studied in the context of infections, vaccinations, and breakthrough infections. Antibodies, however, are pleiotropic proteins that have many functions in addition to neutralization. These include Fc-effector functions such as antibody- dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). Although important to combat viral infections, these Fc-effector functions were less studied in the context of SARS-CoV-2 compared with binding and neutralization. This is partly due to the difficulty in developing reliable assays to measure Fc-effector functions compared to antibody binding and neutralization. Multiple assays have now been developed and can be used to measure different Fc-effector functions. Here, we review these assays and what is known regarding anti-SARS-CoV-2 Fc-effector functions. Overall, this review summarizes and updates our current state of knowledge regarding anti-SARS-CoV-2 Fc-effector functions.

引用

页码：756 / 768

页数：13

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