Deciphering Fc-effector functions against SARS-CoV-2

被引：5

作者：

Beaudoin-Bussieres, Guillaume ^{[1
,2
]}

Finzi, Andres ^{[1
,2
]}

机构：

[1] Ctr Rech CHUM, Montreal, PQ H2X 0A9, Canada

[2] Univ Montreal, Dept Microbiol Infectiol & Immunol, Montreal, PQ H2X 0A9, Canada

来源：

TRENDS IN MICROBIOLOGY | 2024年 / 32卷 / 08期

基金：

加拿大健康研究院;

关键词：

NEUTRALIZING ANTIBODIES; SPIKE; REVEALS; BINDING; PLASMA;

D O I：

10.1016/j.tim.2024.01.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Major efforts were deployed to study the antibody response against SARSCoV-2. Antibodies neutralizing SARS-CoV-2 have been extensively studied in the context of infections, vaccinations, and breakthrough infections. Antibodies, however, are pleiotropic proteins that have many functions in addition to neutralization. These include Fc-effector functions such as antibody- dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). Although important to combat viral infections, these Fc-effector functions were less studied in the context of SARS-CoV-2 compared with binding and neutralization. This is partly due to the difficulty in developing reliable assays to measure Fc-effector functions compared to antibody binding and neutralization. Multiple assays have now been developed and can be used to measure different Fc-effector functions. Here, we review these assays and what is known regarding anti-SARS-CoV-2 Fc-effector functions. Overall, this review summarizes and updates our current state of knowledge regarding anti-SARS-CoV-2 Fc-effector functions.

引用

页码：756 / 768

页数：13

共 124 条

[1] A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples [J].

Ackerman, Margaret E. ;

Moldt, Brian ;

Wyatt, Richard T. ;

Dugast, Anne-Sophie ;

McAndrew, Elizabeth ;

Tsoukas, Stephen ;

Jost, Stephanie ;

Berger, Christoph T. ;

Sciaranghella, Gaia ;

Liu, Qingquan ;

Irvine, Darrell J. ;

Burton, Dennis R. ;

Alter, Galit .

JOURNAL OF IMMUNOLOGICAL METHODS, 2011, 366 (1-2) :8-19

[2] A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19 [J].

Lundgren J.D. ;

Grund B. ;

Barkauskas C.E. ;

Holland T.L. ;

Gottlieb R.L. ;

Sandkovsky U. ;

Brown S.M. ;

Knowlton K.U. ;

Self W.H. ;

Files D.C. ;

Jain M.K. ;

Benfield T. ;

Bowdish M.E. ;

Leshnower B.G. ;

Baker J.V. ;

Jensen J.-U. ;

Gardner E.M. ;

Ginde A.A. ;

Harris E.S. ;

Johansen I.S. ;

Markowitz N. ;

Matthay M.A. ;

Østergaard L. ;

Chang C.C. ;

Davey V.J. ;

Goodman A. ;

Higgs E.S. ;

Murray D.D. ;

Murray T.A. ;

Paredes R. ;

Parmar M.K.B. ;

Phillips A.N. ;

Reilly C. ;

Sharma S. ;

Dewar R.L. ;

Teitelbaum M. ;

Wentworth D. ;

Cao H. ;

Klekotka P. ;

Babiker A.G. ;

Gelijns A.C. ;

Kan V.L. ;

Polizzotto M.N. ;

Thompson B.T. ;

Lane H.C. ;

Neaton J.D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (10) :905-914

[3] COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune Functions [J].

Adeniji, Opeyemi S. ;

Giron, Leila B. ;

Purwar, Mansi ;

Zilberstein, Netanel F. ;

Kulkarni, Abhijeet J. ;

Shaikh, Maliha W. ;

Balk, Robert A. ;

Moy, James N. ;

Forsyth, Christopher B. ;

Liu, Qin ;

Dweep, Harsh ;

Kossenkov, Andrew ;

Weiner, David B. ;

Keshavarzian, Ali ;

Landay, Alan ;

Abdel-Mohsen, Mohamed .

MBIO, 2021, 12 (02)

[4] Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset [J].

Anand, Sai Priya ;

Prevost, Jeremie ;

Nayrac, Manon ;

Beaudoin-Bussieres, Guillaume ;

Benlarbi, Mehdi ;

Gasser, Romain ;

Brassard, Nathalie ;

Laumaea, Annemarie ;

Gong, Shang Yu ;

Bourassa, Catherine ;

Brunet-Ratnasingham, Elsa ;

Medjahed, Halima ;

Gendron-Lepage, Gabrielle ;

Goyette, Guillaume ;

Gokool, Laurie ;

Morrisseau, Chantal ;

Begin, Philippe ;

Martel-Laferriere, Valerie ;

Tremblay, Cecile ;

Richard, Jonathan ;

Bazin, Renee ;

Duerr, Ralf ;

Kaufmann, Daniel E. ;

Finzi, Andres .

CELL REPORTS MEDICINE, 2021, 2 (06)

[5] Understudied Factors Influencing Fc-Mediated Immune Responses against Viral Infections [J].

Anand, Sai Priya ;

Finzi, Andres .

VACCINES, 2019, 7 (03)

[6] Distinct Early Serological Signatures Track with SARS-CoV-2 Survival [J].

Atyeo, Caroline ;

Fischinger, Stephanie ;

Zohar, Tomer ;

Slein, Matthew D. ;

Burke, John ;

Loos, Carolin ;

McCulloch, Denise J. ;

Newman, Kira L. ;

Wolf, Caitlin ;

Yu, Jingyou ;

Shuey, Kiel ;

Feldman, Jared ;

Hauser, Blake Marie ;

Caradonna, Tim ;

Schmidt, Aaron G. ;

Suscovich, Todd J. ;

Linde, Caitlyn ;

Cai, Yongfei ;

Barouch, Dan ;

Ryan, Edward T. ;

Charles, Richelle C. ;

Lauffenburger, Douglas ;

Chu, Helen ;

Alter, Galit .

IMMUNITY, 2020, 53 (03) :524-+

[7] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[8] Covid-19 Vaccines - Immunity, Variants, Boosters [J].

Barouch, Dan H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2022, 387 (11) :1011-1020

[9] REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters [J].

Baum, Alina ;

Ajithdoss, Dharani ;

Copin, Richard ;

Zhou, Anbo ;

Lanza, Kathryn ;

Negron, Nicole ;

Ni, Min ;

Wei, Yi ;

Mohammadi, Kusha ;

Musser, Bret ;

Atwal, Gurinder S. ;

Oyejide, Adelekan ;

Goez-Gazi, Yenny ;

Dutton, John ;

Clemmons, Elizabeth ;

Staples, Hilary M. ;

Bartley, Carmen ;

Klaffke, Benjamin ;

Alfson, Kendra ;

Gazi, Michal ;

Gonzalez, Olga ;

Dick, Edward, Jr. ;

Carrion, Ricardo, Jr. ;

Pessaint, Laurent ;

Porto, Maciel ;

Cook, Anthony ;

Brown, Renita ;

Ali, Vaneesha ;

Greenhouse, Jack ;

Taylor, Tammy ;

Andersen, Hanne ;

Lewis, Mark G. ;

Stahl, Neil ;

Murphy, Andrew J. ;

Yancopoulos, George D. ;

Kyratsous, Christos A. .

SCIENCE, 2020, 370 (6520) :1110-+

[10] A Recent SARS-CoV-2 Infection Enhances Antibody-Dependent Cellular Cytotoxicity against Several Omicron Subvariants following a Fourth mRNA Vaccine Dose [J].

Beaudoin-Bussieres, Guillaume ;

Tauzin, Alexandra ;

Dionne, Katrina ;

Gendron-Lepage, Gabrielle ;

Medjahed, Halima ;

Perreault, Josee ;

Levade, Ines ;

Alfadhli, Laila ;

Bo, Yuxia ;

Bazin, Renee ;

Cote, Marceline ;

Finzi, Andres .

VIRUSES-BASEL, 2023, 15 (06)

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