The Role of Hyperuricemia in Cardiac Diseases: Evidence, Controversies, and Therapeutic Strategies

被引:1
作者
Zheng, Yue [1 ,2 ]
Chen, Zhirui [1 ,2 ]
Yang, Jinya [1 ,2 ]
Zheng, Jing [3 ]
Shui, Xiaorong [4 ]
Yan, Yiguang [1 ,5 ]
Huang, Shian [5 ]
Liang, Zheng [5 ]
Lei, Wei [1 ,2 ,6 ]
He, Yuan [1 ,2 ]
机构
[1] Guangdong Med Univ, Univ Joint Lab Guangdong Prov & Macao Reg Mol Targ, Guangdong Prov Engn Technol Res Ctr Mol Diag & Inn, Affiliated Hosp, Zhanjiang 524001, Peoples R China
[2] Guangdong Med Univ, Affiliated Hosp, Lab Cardiovasc Dis, Zhanjiang 524001, Peoples R China
[3] Univ Wisconsin, Dept Obstet & Gynecol, Madison, WI 53715 USA
[4] Guangdong Med Univ, Affiliated Hosp, Lab Vasc Surg, Zhanjiang 524001, Peoples R China
[5] Guangdong Med Univ, Cardiovasc Med Ctr, Affiliated Hosp, Zhanjiang 524001, Peoples R China
[6] Guangdong Med Univ, Affiliated Hosp, Precis Med Ctr, Zhanjiang 524001, Peoples R China
关键词
hyperuricemia; myocardial injury; acute myocardial infarction; atrial fibrillation; heart failure; SERUM URIC-ACID; ATRIAL-FIBRILLATION; HEART-FAILURE; GOUT; COMORBIDITIES; ASSOCIATION; MORTALITY; IMPACT; LEVEL; URATE;
D O I
10.3390/biom14070753
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Hyperuricemia (HUA) may lead to myocardial cell damage, thereby promoting the occurrence and adverse outcomes of heart diseases. In this review, we discuss the latest clinical research progress, and explore the impact of HUA on myocardial damage-related diseases such as myocardial infarction, arrhythmias, and heart failure. We also combined recent findings from basic research to analyze potential mechanisms linking HUA with myocardial injury. In different pathological models (such as direct action of high uric acid on myocardial cells or combined with myocardial ischemia-reperfusion model), HUA may cause damage by activating the NOD-like receptor protein 3 inflammasome-induced inflammatory response, interfering with cardiac cell energy metabolism, affecting antioxidant defense systems, and stimulating reactive oxygen species production to enhance the oxidative stress response, ultimately resulting in decreased cardiac function. Additionally, we discuss the impact of lowering uric acid intervention therapy and potential safety issues that may arise. However, as the mechanism underlying HUA-induced myocardial injury is poorly defined, further research is warranted to aid in the development novel therapeutic strategies for HUA-related cardiovascular diseases.
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页数:16
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