Relief of Airflow Limitation and Airway Inflammation by Endoscopic Sinus Surgery in a Patient with Severe Asthma with Eosinophilic Chronic Rhinosinusitis

被引:0
|
作者
Matsumori, Kosuke [1 ]
Hamada, Kazuki [2 ]
Oishi, Keiji [2 ]
Okimura, Masatoshi [2 ]
Yonezawa, Kosei [2 ]
Watanabe, Michiya [2 ]
Hisamoto, Yukari [2 ]
Murakawa, Keita [2 ]
Fukatsu-Chikumoto, Ayumi [2 ]
Matsuda, Kazuki [2 ]
Ohata, Syuichiro [2 ]
Suetake, Ryo [2 ]
Utsunomiya, Toshiaki [2 ]
Murata, Yoriyuki [2 ]
Yamaji, Yoshikazu [2 ]
Asami-Noyama, Maki [2 ]
Edakuni, Nobutaka [2 ]
Kakugawa, Tomoyuki [3 ]
Hirano, Tsunahiko [2 ]
Matsunaga, Kazuto [2 ]
机构
[1] Yamaguchi Med Univ, Yamaguchi Ube Med Ctr, Grad Sch, Yamaguchi, Japan
[2] Yamaguchi Univ, Grad Sch Med, Dept Resp Med & Infect Dis, Yamaguchi, Japan
[3] Yamaguchi Univ, Grad Sch Med, Dept Pulmonol & Gerontol, Yamaguchi, Japan
关键词
chronic rhinosinusitis; endoscopic sinus surgery; severe asthma; airflow limitation; asthma remission;
D O I
10.2169/internalmedicine.2918-23
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Although endoscopic sinus surgery (ESS) is beneficial in improving asthma symptoms, its impact on the lung function in patients with asthma and chronic rhinosinusitis remains unclear. We herein report a case of severe asthma with eosinophilic chronic rhinosinusitis, in which ESS substantially improved airflow limitation and concomitantly reduced fractional exhaled nitric oxide and blood eosinophil counts. ESS likely relieved airflow limitation by suppressing type 2 inflammatory pathways. This case highlights ESS as a promising strategy for achieving clinical remission in patients with severe asthma and chronic rhinosinusitis.
引用
收藏
页码:2317 / 2320
页数:4
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