Leucocytosis during all-trans retinoic acid and arsenic trioxide treatment in acute promyelocytic leukaemia

被引：0
|
作者：
Yanada, Masamitsu [1 ]
机构：
[1] Nagoya City Univ, East Med Ctr, 1-2-23 Wakamizu,Chikusa Ku, Nagoya 4648547, Japan
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2024年 / 205卷 / 05期
基金：
日本学术振兴会;
关键词：
acute promyelocytic leukaemia; all-trans retinoic acid; arsenic trioxide; differentiation syndrome; leucocytosis; EARLY DEATH; CENTERS; APL;
D O I：
10.1111/bjh.19763
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In patients with acute promyelocytic leukaemia (APL), differentiation syndrome (DS) is a life-threatening complication caused by the differentiating effect of all-trans retinoic acid (ATRA) and/or arsenic trioxide (ATO). Leucocytosis is frequently observed during induction therapy for APL and is intimately associated with the development of DS and its severity. The management of DS is particularly important due to the high likelihood of excellent outcomes for APL patients who successfully complete induction therapy. Commentary on: Cicconi et al. Leukocytosis during induction therapy with all-trans-retinoic acid and arsenic trioxide in acute promyelocytic leukemia predicts for differentiation syndrome and treatment-related complications. Br J Haematol 2024 (Online ahead of print). doi: .
引用
收藏
页码：1672 / 1673
页数：2
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