Selective Oxidation of Benzo[d]isothiazol-3(2H)-Ones Enabled by Selectfluor

被引：0
作者：
Li, Qin [1 ]
Yuan, Dan [1 ]
Liu, Chong [2 ]
Herington, Faith [2 ]
Yang, Ke [1 ]
Ge, Haibo [2 ]
机构：
[1] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab Adv Catalyt Mat & Technol, Changzhou 213164, Peoples R China
[2] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA
来源：
MOLECULES | 2024年 / 29卷 / 16期
关键词：
Selectfluor; oxidation; benzoisothiazol-3-one-1-oxide; DERIVATIVES;
D O I：
10.3390/molecules29163899
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A metal-free and Selectfluor-mediated selective oxidation reaction of benzo[d]isothiazol-3(2H)-ones in aqueous media is presented. This novel strategy provides a facile, green, and efficient approach to access important benzo[d]isothiazol-3(2H)-one-1-oxides with excellent yields and high tolerance to various functional groups. Furthermore, the purification of benzoisothiazol-3-one-1-oxides does not rely on column chromatography. Moreover, the preparation of saccharine derivatives has been achieved through sequential, double oxidation reactions in a one-pot aqueous media.
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页数：15
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