Aberrant pre-mRNA processing in cancer

被引：2

作者：

Biswas, Jeetayu ^{[1
,2
]}

Boussi, Leora ^{[2
]}

Stein, Eytan ^{[2
]}

Abdel-Wahab, Omar ^{[1
,2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Leukemia Serv, New York, NY 10065 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2024年 / 221卷 / 11期

基金：

美国国家卫生研究院;

关键词：

SPLICING FACTOR SF3B1; 1ST-IN-HUMAN PHASE-I; MYELODYSPLASTIC SYNDROMES; DRIVER MUTATIONS; INTRON RETENTION; GENE-EXPRESSION; UVEAL MELANOMA; INHIBITOR; LEUKEMIA; MODULATION;

D O I：

10.1084/jem.20230891

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This review describes the current state of understanding of how RNA processing is dysregulated in cancer (including alterations in RNA splicing, capping, polyadenylation, and decay) and how this knowledge is being harnessed for therapeutic intent. Dysregulation of the flow of information from genomic DNA to RNA to protein occurs within all cancer types. In this review, we described the current state of understanding of how RNA processing is dysregulated in cancer with a focus on mutations in the RNA splicing factor machinery that are highly prevalent in hematologic malignancies. We discuss the downstream effects of these mutations highlighting both individual genes as well as common pathways that they perturb. We highlight examples of how alterations in RNA processing have been harnessed for therapeutic intent as well as to promote the selective toxicity of cancer cells.

引用

页数：14

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