The epidemiology of Chagas disease in the Americas

被引:28
作者
Cucunuba, Zulma M. [1 ]
Gutierrez-Romero, Sebastian A. [1 ]
Ramirez, Juan-David [2 ,3 ]
Velasquez-Ortiz, Natalia [2 ]
Ceccarelli, Soledad [4 ]
Parra-Henao, Gabriel [5 ]
Henao-Martinez, Andres F. [6 ]
Rabinovich, Jorge [4 ]
Basanez, Maria-Gloria [7 ,8 ]
Nouvellet, Pierre [9 ]
Abad-Franch, Fernando [10 ,11 ]
机构
[1] Pontificia Univ Javeriana, Fac Med, Dept Epidemiol Clin & Bioestadist, Bogota, Colombia
[2] Univ Rosario, Univ Rosario CIMBIUR, Fac Ciencias Nat, Ctr Invest Microbiol & Biotecnol, Bogota, Colombia
[3] Icahn Sch Med Mt Sinai, Dept Pathol Mol & Cell Based Med, Mol Microbiol Lab, New York, NY USA
[4] Univ Nacl La Plata, Ctr Estudios Parasitol & Vectores CEPAVE, La Plata, Argentina
[5] Univ Cooperat Colombia, Ctr Invest Salud Trop, Santa Marta, Colombia
[6] Univ Colorado, Div Infect Dis, Anschutz Med Campus, Aurora, CO USA
[7] Imperial Coll London, Fac Med, Sch Publ Hlth, Dept Infect Dis Epidemiol,MRC Ctr Global Infect Di, London, England
[8] Imperial Coll London, Fac Med, London Ctr Neglected Trop Dis Res, Sch Publ Hlth, London, England
[9] Univ Sussex, Sch Life Sci, Brighton, England
[10] Inst Leonidas & Maria Deane Fiocruz Amazonia, Manaus, Brazil
[11] Univ Fed Minas Gerais, Dept Parasitol, Lab Ecol Parasitos & Vetores LEPaVe, Inst Ciencias Biol, Belo Horizonte, Brazil
来源
LANCET REGIONAL HEALTH-AMERICAS | 2024年 / 37卷
基金
英国医学研究理事会;
关键词
Chagas disease; Trypanosoma cruzi; Transmission; Disease burden; Control; DISCRETE TYPING UNITS; TRYPANOSOMA-CRUZI INFECTION; CONGENITAL TRANSMISSION; BLOOD-DONORS; HEMIPTERA REDUVIIDAE; VECTOR CONTROL; RHODNIUS-PROLIXUS; ORAL-TRANSMISSION; ECO-EPIDEMIOLOGY; RANDOMIZED-TRIAL;
D O I
10.1016/j.lana.2024.100881
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Chagas disease is a complex parasitic zoonosis that still threatens public health across the Americas. Initiatives to control Trypanosoma cruzi transmission via blood transfusion and non-native triatomine-bug vectors have yielded crucial advances; native vectors, however, actively bridge wild and domestic/peri-domestic transmission cycles throughout the region, and tens of thousands of people become infected each year. Oral-transmission outbreaks, urbanisation, and vertical transmission are additional/emerging issues calling for innovative strategic thinking. While critical for advocacy and sustained public health action, assessing Chagas disease burden remains difficult; the often-asymptomatic nature of T. cruzi infection, healthcare access limitations, pervasive underreporting, and other methodological hurdles inherent to reliably measuring incidence, prevalence, and disease progression all contribute to the difficulty. Whether and how parasite, vector, and host genetic makeups affect transmission dynamics and epidemiology is also unclear. Continued high-quality research and long-term, adaptive strategies combining vector control surveillance with enhanced case detection and integral patient care remain critical to effectively address the ethical and societal challenge of Chagas disease control.
引用
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页数:20
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