Maternal antibiotic prophylaxis during cesarean section has a limited impact on the infant gut microbiome

被引：4

作者：

Sinha, Trishla ^{[1
]}

Prins, Jelmer R. ^{[2
]}

Fernandez-Pato, Asier ^{[1
]}

Kruk, Marloes ^{[1
]}

Dierikx, Thomas ^{[3
]}

de Meij, Tim ^{[4
]}

de Boer, Marjon ^{[5
]}

de Boer, Jan Freark ^{[6
,7
]}

Scherjon, Sicco ^{[2
]}

Kurilshikov, Alexander ^{[1
]}

Zhernakova, Alexandra ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Obstet & Gynecol, Groningen, Netherlands

[3] Maastricht Univ Med Ctr, Dept Med Microbiol, Maastricht, Netherlands

[4] Emma Childrens Hosp, Amsterdam UMC, Dept Paediat Gastroenterol, Amsterdam, Netherlands

[5] Amsterdam UMC, Locatie VUmc, Dept Obstet & Gynaecol Reprod & Dev, Amsterdam, Netherlands

[6] Univ Groningen, Univ Med Ctr Groningen, Dept Pediat, Groningen, Netherlands

[7] Univ Groningen, Univ Med Ctr Groningen, Dept Lab Med, Groningen, Netherlands

来源：

CELL HOST & MICROBE | 2024年 / 32卷 / 08期

关键词：

antibiotic resistance genes; cesarean section; feeding mode; infant gut microbiome; maternal prophylactic antibiotics; resistome; strain variability;

D O I：

10.1016/j.chom.2024.07.010

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pregnant women undergoing a cesarean section (CS) typically receive antibiotics prior to skin incision to prevent infections. To investigate if the timing of antibiotics influences the infant gut microbiome, we conducted a randomized controlled trial (NCT06030713) in women delivering via a scheduled CS who received antibiotics either before skin incision or after umbilical cord clamping. We performed a longitudinal analysis on 172 samples from 28 infants at 8 post-birth time points and a cross-sectional analysis at 1 month in 79 infants from 3 cohorts. Although no significant associations with bacterial composition, metabolic pathways, short- chain fatty acids, and bile acids were found, we observed subtle differences between the groups at the bacterial strain level and in the load of antibiotic resistance genes. Rather, feeding mode was a predominant and defining factor impacting infant microbial composition. In conclusion, antibiotic administration during CS has only limited effects on the early-life gut microbiome.

引用

页码：1444 / 1454.e6

页数：18

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