Femtosecond Laser Ionization Mass Spectrometry for Online Analysis of Human Exhaled Breath

被引：1

作者：

Yoshinaga, Katsunori ^{[1
]}

Imasaka, Totaro ^{[2
,3
]}

Imasaka, Tomoko ^{[1
]}

机构：

[1] Kyushu Univ, Fac Design, Fukuoka 8190395, Japan

[2] Kyushu Univ, Fukuoka 8190395, Japan

[3] Hikari Giken Co, Fukuoka 8100024, Japan

来源：

ANALYTICAL CHEMISTRY | 2024年 / 96卷 / 28期

关键词：

VOLATILE ORGANIC-COMPOUNDS; MULTIPHOTON IONIZATION; ALCOHOL-DEHYDROGENASE; GAS-ANALYSIS; ACETONE; MS; NANOSECOND; BIOMARKERS; PROFILE; GC/MS;

D O I：

10.1021/acs.analchem.4c02214

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A variety of organic compounds in human exhaled breath were measured online by mass spectrometry using the fifth (206 nm) and fourth (257 nm) harmonic emissions of a femtosecond ytterbium (Yb) laser as the ionization source. Molecular ions were enhanced significantly by means of resonance-enhanced, two-color, two-photon ionization, which was useful for discrimination of analytes against the background. The limit of detection was 0.15 ppm for acetone in air. The concentration of acetone in exhaled breath was determined for three subjects to average 0.31 ppm, which lies within the range of normal healthy subjects and is appreciably lower than the range for patients with diabetes mellitus. Many other constituents, which could be assigned to acetaldehyde, ethanol, isoprene, phenol, octane, ethyl butanoate, indole, octanol, etc., were observed in the exhaled air. Therefore, the present approach shows potential for use in the online analysis of diabetes mellitus and also for the diagnosis of various diseases, such as COVID-19 and cancers.

引用

页码：11542 / 11548

页数：7

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