Plant-Derived Terpenoids: A Plethora of Bioactive Compounds with Several Health Functions and Industrial Applications-A Comprehensive Overview

被引：39

作者：

Camara, Jose S. ^{[1
,2
]}

Perestrelo, Rosa ^{[1
]}

Ferreira, Rui ^{[1
]}

Berenguer, Cristina V. ^{[1
]}

Pereira, Jorge A. M. ^{[1
]}

Castilho, Paula C. ^{[1
,2
]}

机构：

[1] Univ Madeira, NPRG, CQM Ctr Quim Madeira, Campus Univ Penteada, P-9020105 Funchal, Portugal

[2] Univ Madeira, Fac Ciencias Exatas & Engn, Dept Quim, Campus Univ Penteada, P-9020105 Funchal, Portugal

来源：

MOLECULES | 2024年 / 29卷 / 16期

关键词：

terpenoids; biosynthesis; biosources; bioactive compounds; health benefits; industrial applications; DOXORUBICIN-INDUCED CARDIOTOXICITY; SUPERCRITICAL CARBON-DIOXIDE; ESSENTIAL OILS; APOPTOSIS; INFLAMMATION; EXTRACTION; PROTECTS; RESPONSES; HYDRODISTILLATION; PROLIFERATION;

D O I：

10.3390/molecules29163861

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Terpenoids are a large class of natural secondary plant metabolites which are highly diverse in structure, formed from isoprene units (C-5), associated with a wide range of biological properties, including antioxidant, antimicrobial, anti-inflammatory, antiallergic, anticancer, antimetastatic, antiangiogenesis, and apoptosis induction, and are considered for potential application in the food, cosmetics, pharmaceutical, and medical industries. In plants, terpenoids exert a variety of basic functions in growth and development. This review gives an overview, highlighting the current knowledge of terpenoids and recent advances in our understanding of the organization, regulation, and diversification of core and specialized terpenoid metabolic pathways and addressing the most important functions of volatile and non-volatile specialized terpenoid metabolites in plants. A comprehensive description of different aspects of plant-derived terpenoids as a sustainable source of bioactive compounds, their biosynthetic pathway, the several biological properties attributed to these secondary metabolites associated with health-promoting effects, and their potential industrial applications in several fields will be provided, and emerging and green extraction methods will also be discussed. In addition, future research perspectives within this framework will be highlighted. Literature selection was carried out using the National Library of Medicine, PubMed, and international reference data for the period from 2010 to 2024 using the keyword "terpenoids". A total of 177,633 published papers were found, of which 196 original and review papers were included in this review according to the criteria of their scientific reliability, their completeness, and their relevance to the theme considered.

引用

页数：35

共 198 条

[11] Floral Odors and the Interaction between Pollinating Ceratopogonid Midges and Cacao [J].

Arnold, Sarah E. J. ;

Forbes, Samantha J. ;

Hall, David R. ;

Farman, Dudley, I ;

Bridgemohan, Puran ;

Spinelli, Gustavo R. ;

Bray, Daniel P. ;

Perry, Garvin B. ;

Grey, Leroy ;

Belmain, Steven R. ;

Stevenson, Philip C. .

JOURNAL OF CHEMICAL ECOLOGY, 2019, 45 (10) :869-878

[12] Green Extraction of Bioactive Compounds from Plant Biomass and Their Application in Meat as Natural Antioxidant [J].

Awad, Alzaidi Mohammed ;

Kumar, Pavan ;

Ismail-Fitry, Mohammad Rashedi ;

Jusoh, Shokri ;

Ab Aziz, Muhamad Faris ;

Sazili, Awis Qurni .

ANTIOXIDANTS, 2021, 10 (09)

[13] Renoprotective effects of artemisinin and hydroxychloroquine combination therapy on IgA nephropathy via suppressing NF-κB signaling and NLRP3 inflammasome activation by exosomes in rats [J].

Bai, Lixia ;

Li, Jicheng ;

Li, Honglian ;

Song, Jianping ;

Zhou, Yuan ;

Lu, Ruirui ;

Liu, Bihao ;

Pang, Yu ;

Zhang, Peichun ;

Chen, Junqi ;

Liu, Xusheng ;

Wu, Junbiao ;

Liang, Chunling ;

Zhou, Jiuyao .

BIOCHEMICAL PHARMACOLOGY, 2019, 169

[14] Myrcene Exhibits Antitumor Activity Against Lung Cancer Cells by Inducing Oxidative Stress and Apoptosis Mechanisms [J].

Bai, Xudong ;

Tang, Jin .

NATURAL PRODUCT COMMUNICATIONS, 2020, 15 (09)

[15] Anti-Tumor Drug Discovery Based on Natural Product β-Elemene: Anti-Tumor Mechanisms and Structural Modification [J].

Bai, Ziqiang ;

Yao, Chuansheng ;

Zhu, Junlong ;

Xie, Yuanyuan ;

Ye, Xiang-Yang ;

Bai, Renren ;

Xie, Tian .

MOLECULES, 2021, 26 (06)

[16] The Use of 11-Elemene to Enhance Radio Sensitization of A375 Human Melanoma Cells [J].

Balavandi, Zahra ;

Neshasteh-Riz, Ali ;

Koosha, Fereshteh ;

Eynali, Samira ;

Hoormand, Mahmood ;

Shahidi, Minoo .

CELL JOURNAL, 2020, 21 (04) :419-425

[17] Terpenes and Terpenoids in Plants: Interactions with Environment and Insects [J].

Boncan, Delbert Almerick T. ;

Tsang, Stacey S. K. ;

Li, Chade ;

Lee, Ivy H. T. ;

Lam, Hon-Ming ;

Chan, Ting-Fung ;

Hui, Jerome H. L. .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (19) :1-19

[18] Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome [J].

Bridgford, Jessica L. ;

Xie, Stanley C. ;

Cobbold, Simon A. ;

Pasaje, Charisse Flerida A. ;

Herrmann, Susann ;

Yang, Tuo ;

Gillett, David L. ;

Dick, Lawrence R. ;

Ralph, Stuart A. ;

Dogovski, Con ;

Spillman, Natalie J. ;

Tilley, Leann .

NATURE COMMUNICATIONS, 2018, 9

[19] Green Extraction Techniques as Advanced Sample Preparation Approaches in Biological, Food, and Environmental Matrices: A Review [J].

Camara, Jose S. ;

Perestrelo, Rosa ;

Berenguer, Cristina V. ;

Andrade, Carolina F. P. ;

Gomes, Telma M. ;

Olayanju, Basit ;

Kabir, Abuzar ;

M. R. Rocha, Cristina ;

Teixeira, Jose Antonio ;

Pereira, Jorge A. M. .

MOLECULES, 2022, 27 (09)

[20] Toxicological evaluation of essential oil from the leaves of Croton tetradenius (Euphorbiaceae) on Aedes aegypti and Mus musculus [J].

Carvalho, Karine da Silva ;

da Cunha e Silva, Sandra Lucia ;

de Souza, Ivone Antonia ;

Gualberto, Simone Andrade ;

Dantas da Cruz, Romulo Carlos ;

dos Santos, Frances Regiane ;

de Carvalho, Mario Geraldo .

PARASITOLOGY RESEARCH, 2016, 115 (09) :3441-3448

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