Utilization of polymeric carriers for (E)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol- E )-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol- 4-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one as anticancer agent

被引：0

作者：

Mohamed, Ayda A. ^{[1
,2
]}

Ayad, D. M. ^{[1
]}

Al-Subbagh, H. ^{[3
]}

Abdelaal, M. Y. ^{[1
]}

机构：

[1] Mansoura Univ, Fac Sci, Chem Dept, Mansoura 35516, Egypt

[2] Horus Univ Egypt, Fac Pharm, New Damietta, Egypt

[3] Mansoura Univ, Fac Pharm, Med Chem Dept, Mansoura, Egypt

来源：

EGYPTIAN JOURNAL OF CHEMISTRY | 2024年 / 67卷 / 02期

关键词：

1; 2; 3-triazole chalcone hybrid; anticancer activity; chitosan; CMC; controlled release; CHALCONE; DERIVATIVES; CHITOSAN;

D O I：

10.21608/EJCHEM.2023.214817.8068

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the current work, 4-nitroaniline (1) reacted with sodium azide to produce 4-nitrophenyl azide (2) and converted into the corresponding 1,2,3-triazole derivative (3). . The obtained 1,2,3-triazole derivative (3) converted into (E)-1-[5-methyl-1-(4- E )-1-[5-methyl-1-(4- nitrophenyl)triazol-4-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (4) through Claisen-Schmidt condensation with 3,4,5trihydroxybenzaldehyde in ethanolic NaOH. Compound 4 was then characterized with the suitable spectroscopic techniques and investigated for its anticancer activity. Blends of 4 with Chitosan (CS) and carboxymethylcellulose (CMC) were prepared by uploading it into the polymer matrices through physical mixing. The release behavior of 4 from the polymer blends into an aqueous medium at room temperature was investigated and discussed.

引用

页码：487 / 495

页数：9

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