Utilization of polymeric carriers for (E)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol- E )-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol- 4-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one as anticancer agent

In the current work, 4-nitroaniline (1) reacted with sodium azide to produce 4-nitrophenyl azide (2) and converted into the corresponding 1,2,3-triazole derivative (3). . The obtained 1,2,3-triazole derivative (3) converted into (E)-1-[5-methyl-1-(4- E )-1-[5-methyl-1-(4- nitrophenyl)triazol-4-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (4) through Claisen-Schmidt condensation with 3,4,5trihydroxybenzaldehyde in ethanolic NaOH. Compound 4 was then characterized with the suitable spectroscopic techniques and investigated for its anticancer activity. Blends of 4 with Chitosan (CS) and carboxymethylcellulose (CMC) were prepared by uploading it into the polymer matrices through physical mixing. The release behavior of 4 from the polymer blends into an aqueous medium at room temperature was investigated and discussed.