Loopy virus or controlled contortionist? 3D regulation of HCMV gene expression by CTCF-driven chromatin interactions

被引：1
作者：
Groves, Ian J. [1 ,2 ]
OConnor, Christine M. [1 ,2 ]
机构：
[1] Cleveland Clin, Lerner Res Inst, Global Ctr Pathogen & Human Hlth Res, Infect Biol Program, Cleveland, OH 44195 USA
[2] Case Western Reserve Univ, Cleveland Clin, Mol Med, Lerner Coll Med, Cleveland, OH 44195 USA
来源：
JOURNAL OF VIROLOGY | 2024年
基金：
美国国家卫生研究院;
关键词：
herpesvirus; HHV; epigenetics; chromatin; cytomegalovirus; CMV; HCMV; CTCF; BINDING; DNA; ORGANIZATION; COHESIN;
D O I：
10.1128/jvi.01148-24
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Three-dimensional chromatin control of eukaryotic transcription is pivotal for regulating gene expression. This additional layer of epigenetic regulation is also utilized by DNA viruses, including herpesviruses. Dynamic, spatial genomic organization often involves looping of chromatin anchored by host-encoded CCCTC-binding factor (CTCF) and other factors, which control crosstalk between promoters and enhancers. Herein, we review the contribution of CTCF-mediated looping in regulating transcription during herpesvirus infection, with a specific focus on the betaherpesvirus, human cytomegalovirus (HCMV).
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页数：7
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