Synthesis and assessment of piroxicam derivatives as potential chelating agents and antioxidants for lead poisoning treatment

被引：0
作者：
Salmani, Ali [1 ,2 ]
Imani, Ali [3 ]
Zibaseresht, Ramin [4 ,5 ,6 ]
Koudehi, Masoumeh Foroutan [1 ,2 ]
Khajeh-Amiri, Alireza [1 ]
Heidari, Reza [7 ,8 ]
Chamanara, Mohsen [1 ,9 ]
Fasihi, Hossein [1 ,2 ]
机构：
[1] AJA Univ Med Sci, Toxicol Res Ctr, Tehran, Iran
[2] AJA Univ Med Sci, Biomat & Med Chem Res Ctr, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Med Chem, Tehran, Iran
[4] Univ Canterbury, Dept Chem Christchurch, Christchurch, New Zealand
[5] Univ Canterbury, Dept Chem & Phys, Christchurch, New Zealand
[6] Maritime Univ Imam Khomeini, Tehran, Iran
[7] AJA Univ Med Sci, Canc Epidemiol Res Ctr AJA CERTC, Tehran, Iran
[8] AJA Univ Med Sci, Med Biotechnol Res Ctr, Tehran, Iran
[9] AJA Univ Med Sci, Student Res Comm, Tehran, Iran
来源：
RESULTS IN CHEMISTRY | 2024年 / 11卷
关键词：
Lead chelators; Toxic metal; Piroxicam derivative; OXIDATIVE STRESS; ANTIINFLAMMATORY DRUGS; BIOLOGICAL EVALUATION; COMPLEXES; TOXICITY; EXPOSURE; ASSAY;
D O I：
10.1016/j.rechem.2024.101768
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Lead is a highly harmful environmental and occupational contaminant that works by inducing oxidative stress. Chelation therapy is the only treatment available in clinics for heavy metal poisoning, but it also has several adverse effects. This work assessed the in-vitro prevention effect of synthesized piroxicam derivatives for lead poisoning using the jobs techniques and NMR spectroscopy. Subsequently, in the presence of lead nitrate, the cytoprotection of piroxicam derivatives was assessed and compared with EDTA as an effective chelator. As a result, all synthesized compounds effectively chelated the lead ions. Furthermore, possibly due to the antioxidant activity of piroxicam derivatives, these compounds were even more effective in preventing cell death caused by lead poisoning than EDTA. The results showed that piroxicam derivatives are helpful in metal poisoning treatment due to their chelation ability and antioxidant activity.
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页数：8
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