Palladium-catalyzed cyclization borylmethylation: Access to boryl-functionalized benzene-fused heterocycle compounds

被引：1

作者：

Li, Qi ^{[1
]}

Ye, Wenjun ^{[1
]}

Cui, Huanhuan ^{[1
]}

Liu, Bowen ^{[1
]}

Zhang, Chun ^{[1
,2
]}

机构：

[1] Tianjin Univ, Inst Mol Plus, Sch Pharmaceut Sci & Technol, Fac Med,Dept Chem, Weijin Rd 92, Tianjin 300072, Peoples R China

[2] Tianjin Key Lab Innovat Drugs Targeting Cent Nervo, Lanyuan Rd 5, Tianjin 300384, Peoples R China

来源：

TETRAHEDRON LETTERS | 2024年 / 148卷

基金：

中国国家自然科学基金;

关键词：

Coupling reaction; Palladium-catalysis; Boration; Heterocyclic; Cyclization; ALLYLIC SUBSTITUTION; GEM-DIBORYLALKANES; ARYL-ALKENYLATION; DOMINO; DIBORYLMETHANE; DIASTEREO; ENANTIO; 1,1-DIBORYLALKANES; HYDROARYLATION; COUPLINGS;

D O I：

10.1016/j.tetlet.2024.155216

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed intramolecular cyclization borylmethylation of alkene-tethered aryl iodide with 1,1-diborylmethane has been described. This method offers an efficient route to synthesize various benzo-heterocyclic compounds containing oxygen or nitrogen atoms. Further experiments have demonstrated that the products can be employed to synthesize a series of potentially biological active heterocyclic compounds.

引用

页数：5

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