Tumor-infiltrating lymphocytes A new hope

被引：23
作者：
Sarnaik, Amod A. [1 ,2 ]
Hwu, Patrick [1 ,2 ]
Mule, James J. [1 ,2 ]
Pilon-Thomas, Shari [1 ,3 ]
机构：
[1] H Lee Moffitt Canc Ctr & Res Inst, Immunol Program, Tampa, FL 33612 USA
[2] H Lee Moffitt Canc Ctr & Res Inst, Cutaneous Oncol Program, Tampa, FL 33612 USA
[3] H Lee Moffitt Canc Ctr & Res Inst, Ctr Immunizat & Infect Res Canc, Tampa, FL USA
来源：
CANCER CELL | 2024年 / 42卷 / 08期
关键词：
T-CELLS; IMMUNOTHERAPY; CANCER;
D O I：
10.1016/j.ccell.2024.06.015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumor-infiltrating lymphocytes (TILs) can be massively expanded from resected tumors and used as a cellular treatment for advanced malignancies. TILs require a preparative non-myeloablative chemotherapy followed by an abbreviated course of interleukin-2. Here, we review the historical development of TIL therapy and discuss potential solutions to ongoing roadblocks that may result in broader and improved efficacy for patients afflicted with treatment-refractory, advanced cancer.
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页数：4
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