Tumor-infiltrating lymphocytes A new hope

被引：8
|
作者：
Sarnaik, Amod A. [1 ,2 ]
Hwu, Patrick [1 ,2 ]
Mule, James J. [1 ,2 ]
Pilon-Thomas, Shari [1 ,3 ]
机构：
[1] H Lee Moffitt Canc Ctr & Res Inst, Immunol Program, Tampa, FL 33612 USA
[2] H Lee Moffitt Canc Ctr & Res Inst, Cutaneous Oncol Program, Tampa, FL 33612 USA
[3] H Lee Moffitt Canc Ctr & Res Inst, Ctr Immunizat & Infect Res Canc, Tampa, FL USA
来源：
CANCER CELL | 2024年 / 42卷 / 08期
关键词：
T-CELLS; IMMUNOTHERAPY; CANCER;
D O I：
10.1016/j.ccell.2024.06.015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumor-infiltrating lymphocytes (TILs) can be massively expanded from resected tumors and used as a cellular treatment for advanced malignancies. TILs require a preparative non-myeloablative chemotherapy followed by an abbreviated course of interleukin-2. Here, we review the historical development of TIL therapy and discuss potential solutions to ongoing roadblocks that may result in broader and improved efficacy for patients afflicted with treatment-refractory, advanced cancer.
引用
收藏
页数：4
相关论文
共 50 条
  • [1] Tumor-Infiltrating Lymphocytes Clinical Experience
    Besser, Michal J.
    Shapira-Frommer, Ronnie
    Schachter, Jacob
    CANCER JOURNAL, 2015, 21 (06) : 465 - 469
  • [2] Tumor-Infiltrating Lymphocytes in Melanoma
    Lee, Sylvia
    Margolin, Kim
    CURRENT ONCOLOGY REPORTS, 2012, 14 (05) : 468 - 474
  • [3] The role of tumor-infiltrating lymphocytes in cholangiocarcinoma
    Liu, Dong
    Heij, Lara Rosaline
    Czigany, Zoltan
    Dahl, Edgar
    Lang, Sven Arke
    Ulmer, Tom Florian
    Luedde, Tom
    Neumann, Ulf Peter
    Bednarsch, Jan
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2022, 41 (01)
  • [4] Tumor-infiltrating lymphocytes in the immunotherapy era
    Sterre T. Paijens
    Annegé Vledder
    Marco de Bruyn
    Hans W. Nijman
    Cellular & Molecular Immunology, 2021, 18 : 842 - 859
  • [5] Tumor-infiltrating lymphocytes in the immunotherapy era
    Paijens, Sterre T.
    Vledder, Annege
    de Bruyn, Marco
    Nijman, Hans W.
    CELLULAR & MOLECULAR IMMUNOLOGY, 2021, 18 (04) : 842 - 859
  • [6] Tumor-Infiltrating Lymphocytes in Wilms Tumor
    Yadav, Devendra Kumar
    Jain, Vishesh
    Dinda, Amit Kumar
    Agarwala, Sandeep
    INDIAN JOURNAL OF MEDICAL AND PAEDIATRIC ONCOLOGY, 2020, 41 (01) : 34 - 38
  • [7] Tumor-Infiltrating Lymphocytes in Melanoma
    Sylvia Lee
    Kim Margolin
    Current Oncology Reports, 2012, 14 : 468 - 474
  • [8] Tumor-Infiltrating Lymphocytes in the Checkpoint Inhibitor Era
    Linette, Gerald P.
    Carreno, Beatriz M.
    CURRENT HEMATOLOGIC MALIGNANCY REPORTS, 2019, 14 (04) : 286 - 291
  • [9] Tumor-infiltrating lymphocytes in breast FNA biopsy cytology: a predictor of tumor-infiltrating lymphocytes in histologic evaluation
    Odate, Toru
    Le, Minh-Khang
    Kawai, Masataka
    Kubota, Mizuki
    Yamaguchi, Yohei
    Kondo, Tetsuo
    CANCER CYTOPATHOLOGY, 2022, 130 (05) : 336 - 343
  • [10] The role of tumor-infiltrating lymphocytes in cholangiocarcinoma
    Dong Liu
    Lara Rosaline Heij
    Zoltan Czigany
    Edgar Dahl
    Sven Arke Lang
    Tom Florian Ulmer
    Tom Luedde
    Ulf Peter Neumann
    Jan Bednarsch
    Journal of Experimental & Clinical Cancer Research, 41
12345