Postoperative delayed gastric emptying: may gut microbiota play a role?

被引：2
作者：
Wang, Zhiyi [1 ,2 ]
Liu, Chuanbo [1 ]
Hu, Kaiwen [1 ]
Zuo, Minghuan [1 ]
Tian, Zhen [1 ]
Wei, Yue [1 ]
Zhou, Qin [1 ]
Li, Quanwang [1 ]
机构：
[1] Univ Chinese Med, Grad Sch Beijing, Beijing, Peoples R China
[2] Beijing Univ Chinese Med, Dongfang Hosp, Dept Oncol, Beijing, Peoples R China
来源：
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2024年 / 14卷
基金：
中国国家自然科学基金;
关键词：
postoperative delayed gastric emptying; gut microbiota; postoperative complications; gastric emptying; gastroparesis; PROTON PUMP INHIBITORS; CENTRAL-NERVOUS-SYSTEM; CHAIN FATTY-ACIDS; GASTROINTESTINAL MOTILITY; BRAIN AXIS; MUSCULARIS MACROPHAGES; DOUBLE-BLIND; GHRELIN; IMPACT; GASTROPARESIS;
D O I：
10.3389/fcimb.2024.1449530
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Postoperative delayed gastric emptying is a prevalent complication following surgical procedures, imposing heavy physical and financial burdens on patients. However, current treatment options remain suboptimal. In recent years, an increasing number of studies have highlighted that the gut microbiota and its metabolites are closely associated with postoperative complications. Various factors can disrupt the gut microbiome after surgery. This review discusses the potential mechanisms by which the gut microbiota and their metabolites may contribute to the pathogenesis of postoperative delayed gastric emptying. However, the current knowledge base is limited in terms of fully understanding the exact mechanisms involved. It is therefore evident that further research is required to fully elucidate the role of the gut microbiome in postoperative delayed gastric emptying, with the aim of uncovering new possibilities for preventive measures and therapeutic treatments.
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页数：12
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