Polymer blends innovation: Advancement in novel drug delivery

被引：0

作者：

Bramhe, Pratiksha ^{[1
]}

Waghmare, Suchita ^{[1
]}

Rarokar, Nilesh ^{[2
]}

Sabale, Prafulla ^{[1
]}

Khedekar, Pramod ^{[1
]}

Sabale, Vidya ^{[3
]}

Potey, Lata ^{[4
]}

机构：

[1] Tukadoji Maharaj Nagpur Univ Nagpur, Dept Pharmaceut Sci Rashtrasant, Nagpur, Maharashtra, India

[2] Hingna MIDC, GH Raisoni Inst Life Sci, Nagpur, India

[3] Dadasaheb Balpande Coll Pharm, Nagpur, Maharashtra, India

[4] Shree Sainath Coll Pharm, Nagpur, Maharashtra, India

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2024年

关键词：

Gene therapy; implants-based drug delivery; modified polymers; surface functionalization; PHOTO-CROSS-LINKING; CLICK-CHEMISTRY; SURFACE MODIFICATION; GENE DELIVERY; IN-VITRO; BIODEGRADABLE POLYMERS; SYSTEMS; BIOMATERIALS; CHITOSAN; SCAFFOLDS;

D O I：

10.1080/00914037.2024.2387026

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The integration of polymers and modified polymers in diverse drug delivery systems, including implants, gene delivery, and nano-based approaches, has significantly advanced therapeutic interventions. Implants-based drug delivery, utilizing bio-degradable polymers like poly(lactic-co-glycolic acid)(PLGA) and polycaprolactone(PCL), demonstrates efficacy in sustained release, enhancing patient compliance. Polymers synergize with gene delivery systems, efficiently targeting genetic material delivery and overcoming gene therapy challenges. In nano-based drug delivery, polymer-based nanoparticles (micelles, dendrimers, nanogels) provide precise control over release kinetics, improved uptake, and enhanced bioavailability. This review underscores polymers' pivotal role in developing advanced drug delivery, improving efficacy, and reducing systemic toxicity. [GRAPHICS]

引用

页数：18

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