Bioinformatics-based analysis of the dialog between COVID-19 and RSA

被引：2
作者：
Bi, Yin [1 ,2 ,3 ]
Li, Ting [1 ,2 ,3 ]
Zhang, Shun [4 ]
Yang, Yihua [1 ,2 ,3 ]
Dong, Mingyou [1 ,5 ]
机构：
[1] Guangxi Med Univ, Guangxi Reprod Med Ctr, Affiliated Hosp 1, Nanning 530000, Peoples R China
[2] Guangxi Med Univ, Guangxi Key Lab Immunol & Metab Liver Dis, Nanning 530000, Peoples R China
[3] Guangxi Med Univ, Key Lab Early Prevent & Treatment Reg High Frequen, Minist Educ, Nanning 530000, Peoples R China
[4] Guilin Med Univ, Dept Reprod, Affiliated Hosp, Med Ctr, Guilin 541001, Guangxi, Peoples R China
[5] Youjiang Med Univ Nationalities, Key Lab Mol Pathol For Hepatobiliary Dis Guangxi, Affiliated Hosp, Baise 533000, Peoples R China
来源：
HELIYON | 2024年 / 10卷 / 09期
关键词：
COVID-19; Recurrent spontaneous abortion; Common differentially expressed genes; Central hub genes; Small molecular compounds; RECURRENT; GENE; EXPRESSION; DEGRADATION; BIOGENESIS; ACTIVATION; EVOLUTION; GENOMICS; DISGENET; TARGETS;
D O I：
10.1016/j.heliyon.2024.e30371
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Pregnant women infected with SARS-CoV-2 in early pregnancy may face an increased risk of miscarriage due to immune imbalance at the maternal-fetal interface. However, the molecular mechanisms underlying the crosstalk between COVID-19 infection and recurrent spontaneous abortion (RSA) remain poorly understood. This study aimed to elucidate the transcriptomic molecular dialog between COVID-19 and RSA. Based on bioinformatics analysis, 307 common differentially expressed genes were found between COVID-19 (GSE171110) and RSA (GSE165004). Common DEGs were mainly enriched in ribosome-related and cell cycle-related signaling pathways. Using degree algorithm, the top 10 hub genes (RPS27A, RPL5, RPS8, RPL4, RPS2, RPL30, RPL23A, RPL31, RPL26, RPL37A) were selected from the common DEGs based on their scores. The results of the qPCR were in general agreement with the results of the raw letter analysis. The top 10 candidate drugs were also selected based on P-values. In this study, we provide molecular markers, signaling pathways, and small molecule compounds that may associate COVID-19. These findings may increase the accurate diagnosis and treatment of COVID-19 patients.
引用
收藏
页数：16
相关论文
共 76 条
[1]   Association of Vitamin D receptor gene polymorphisms and clinical/severe outcomes of COVID-19 patients [J].
Abdollahzadeh, Rasoul ;
Shushizadeh, Mohammad Hossein ;
Barazandehrokh, Mina ;
Choopani, Sepideh ;
Azarnezhad, Asaad ;
Paknahad, Sahereh ;
Pirhoushiaran, Maryam ;
Makani, S. Zahra ;
Yeganeh, Razieh Zarifian ;
Al-Kateb, Ahmed ;
Heidarzadehpilehrood, Roozbeh .
INFECTION GENETICS AND EVOLUTION, 2021, 96
[2]   A Molecular Bridge: Connecting Type 2 Diabetes and Alzheimer's Disease [J].
Ahmed, Firoz ;
Ansari, Juned Asghar ;
Ansari, Zahid Eqbal ;
Alam, Qamre ;
Gan, Siew Hua ;
Kamal, Mohammad A. ;
Ahmad, Ejaj .
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2014, 13 (02) :312-321
[3]   Fetomaternal immune cross-talk and its consequences for maternal and offspring's health [J].
Arck, Petra C. ;
Hecher, Kurt .
NATURE MEDICINE, 2013, 19 (05) :548-556
[4]   Association of genetic variants in Estrogen receptor (ESR)1 and ESR2 with susceptibility to recurrent pregnancy loss in Tunisian women: A case control study [J].
Bahia, Wael ;
Soltani, Ismael ;
Haddad, Anis ;
Soua, Aymen ;
Radhouani, Assala ;
Mahdhi, Abdelkarim ;
Ferchichi, Salima .
GENE, 2020, 736
[5]   Proinflammatory cytokines induced altered expression of cyclooxygenase-2 gene results in unreceptive endometrium in women with idiopathic recurrent spontaneous miscarriage [J].
Banerjee, Priyanka ;
Jana, Saikat Kumar ;
Pasricha, Pallavi ;
Ghosh, Sanghamitra ;
Chakravarty, Baidyanath ;
Chaudhury, Koel .
FERTILITY AND STERILITY, 2013, 99 (01) :179-U551
[6]   MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].
Bartel, David P. .
CELL, 2007, 131 (04) :11-29
[7]   Transcriptional Regulation by p53 [J].
Beckerman, Rachel ;
Prives, Carol .
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2010, 2 (08) :a000935
[8]   Sperm gene expression profile is related to pregnancy rate after insemination and is predictive of low fecundity in normozoospermic men [J].
Bonache, Sandra ;
Mata, Ana ;
Dolores Ramos, Maria ;
Bassas, Lluis ;
Larriba, Sara .
HUMAN REPRODUCTION, 2012, 27 (06) :1556-1567
[9]   The complement system at the embryo implantation site: friend or foe? [J].
Bulla, R. ;
Bossi, F. ;
Tedesco, F. .
FRONTIERS IN IMMUNOLOGY, 2012, 3
[10]   Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress [J].
Bursac, Sladana ;
Brdovcak, Maja Cokaric ;
Pfannkuchen, Martin ;
Orsolic, Ines ;
Golomb, Lior ;
Zhu, Yan ;
Katz, Chen ;
Daftuar, Lilyn ;
Grabusic, Kristina ;
Vukelic, Iva ;
Filic, Vedrana ;
Oren, Moshe ;
Prives, Carol ;
Volarevic, Sinisa .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (50) :20467-20472
12345678