Omeprazole affects the expression of serotonin-1A in the brain regions and alleviates anxiety in rat model of immobilization-induced stress

被引：0
作者：
Ali, Sadia Basharat [1 ]
Saeed, Raheel [1 ,2 ]
Mahmood, Khalid [1 ]
Haleem, Darakhshan Jabeen [1 ]
机构：
[1] Univ Karachi, Dr Panjwani Ctr Mol Med & Drug Res, Int Ctr Chem & Biol Sci, Neurosci Res Lab, KU Circular Rd, Karachi 75270, Pakistan
[2] Salim Habib Univ, Dept Basic Med Sci, Fac Pharm, Karachi, Pakistan
来源：
BEHAVIOURAL PHARMACOLOGY | 2024年 / 35卷 / 07期
关键词：
anxiety; hippocampus; immobilization stress; omeprazole; raphe; rat; serotonin-1A receptor; RECEPTORS; HIPPOCAMPAL; CIRRHOSIS; FEEDBACK; DEFICITS;
D O I：
10.1097/FBP.0000000000000793
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Omeprazole, a drug of choice for the management of gastric hyperacidity, influences serotonergic neurotransmission in brain regions and its long-term use is known to cause stress-related behavioral deficits including anxiety. Aim of the current study was to explore the effects of omeprazole treatment on immobilization-induced anxiety in rats, specifically on the role of serotonin (5-HT). In view of the role of serotonin-1A (5-HT1A) autoreceptor in the availability of 5-HT in brain regions, mRNA expression of this autoreceptor was performed in raphe nuclei. Similarly, because of the role of hippocampal 5-HT neurotransmission in anxiety-like disorders, expression of the 5-HT1A heteroreceptors was determined in this region. We found that the treatment with omeprazole reduces anxiety-like behavior in rats, increases the expression of 5-HT1A autoreceptor in the raphe and decreases the hippocampal expression of 5-HT1A heteroreceptor. This suggests a role of 5-HT1A receptor types in omeprazole-induced behavioral changes. It also indicates a potential role of omeprazole in the management of serotonergic disorders.
引用
收藏
页码：408 / 417
页数：10
相关论文
共 41 条
  • [1] Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm
    Albert, Paul R.
    Le Francois, Brice
    Vahid-Ansari, Faranak
    [J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE, 2019, 44 (03): : 164 - 176
  • [2] Elevated anxiety, hypoactivity, memory deficits, decreases of brain serotonin and 5-HT-1A receptors expression in rats treated with omeprazole
    Ali, Sadia Basharat
    Mahmood, Khalid
    Saeed, Raheel
    Salman, Tabinda
    Choudhary, Muhammad Iqbal
    Haleem, Darakhshan Jabeen
    [J]. TOXICOLOGICAL RESEARCH, 2021, 37 (02) : 237 - 248
  • [3] Rethinking 5-HT1A Receptors: Emerging Modes of Inhibitory Feedback of Relevance to Emotion-Related Behavior
    Altieri, Stefanie C.
    Garcia-Garcia, Alvaro L.
    Leonardo, E. David
    Andrews, Anne M.
    [J]. ACS CHEMICAL NEUROSCIENCE, 2013, 4 (01): : 72 - 83
  • [4] Atrooz Fatin, 2021, Curr Res Neurobiol, V2, P100013, DOI 10.1016/j.crneur.2021.100013
  • [5] Instantaneous enteric nano-encapsulation of omeprazole: Pharmaceutical and pharmacological evaluation
    Bendas, Ehab R.
    Abdelbary, Aly A.
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2014, 468 (1-2) : 97 - 104
  • [6] Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole-In Vitro and In Vivo Investigations
    Betari, Nibal
    Sahlholm, Kristoffer
    Morato, Xavier
    Godoy-Marin, Hector
    Jauregui, Olga
    Teigen, Knut
    Ciruela, Francisco
    Haavik, Jan
    [J]. FRONTIERS IN PHARMACOLOGY, 2020, 11
  • [7] Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice
    Birnie, Matthew T. T.
    Short, Annabel K. K.
    de Carvalho, Gregory B. B.
    Taniguchi, Lara
    Gunn, Benjamin G. G.
    Pham, Aidan L. L.
    Itoga, Christy A. A.
    Xu, Xiangmin
    Chen, Lulu Y. Y.
    Mahler, Stephen V. V.
    Chen, Yuncai
    Baram, Tallie Z. Z.
    [J]. NATURE COMMUNICATIONS, 2023, 14 (01)
  • [8] 5HT-1A receptors and anxiety-like behaviours: Studies in rats with constitutionally upregulated/downregulated serotonin transporter
    Bordukalo-Niksic, Tatjana
    Mokrovic, Gordana
    Stefulj, Jasminka
    Zivin, Marko
    Jernej, Branimir
    Cicin-Sain, Lipa
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2010, 213 (02) : 238 - 245
  • [9] In vivo and in vitro protective effects of omeprazole against neuropathic pain
    Chanchal, Sanjay K.
    Mahajan, Umesh B.
    Siddharth, Sumit
    Reddy, Navyya
    Goyal, Sameer N.
    Patil, Prakash H.
    Bommanahalli, Basavaraj P.
    Kundu, Chanakya N.
    Patil, Chandragouda R.
    Ojha, Shreesh
    [J]. SCIENTIFIC REPORTS, 2016, 6
  • [10] Cheema MAR, 2018, NUTR NEUROSCI, V21, P185, DOI [10.1080/1028415x.2016.1257417, 10.1080/1028415X.2016.1257417]
12345