Surveillance of avian influenza viruses in Hebei Province of China from 2021 to 2023: Identification of a novel reassortant H3N3

被引:2
作者
Li, Yanbai [1 ]
Yin, Zhe [1 ]
Wang, Juan [1 ]
Xu, Yujuan [2 ]
Huo, Shanshan [1 ]
Wu, Yang [1 ]
Dou, Dou [1 ]
Han, Qingan [3 ]
Jiang, Shibo [4 ]
Li, Feng [2 ]
Liu, Peng [1 ]
Yu, Fei [1 ]
机构
[1] Hebei Agr Univ, Coll Life Sci, Hebei Wild Anim Hlth Ctr, Hebei Key Lab Anal & Control Zoonot Pathogen Micro, Baoding, Peoples R China
[2] Guangzhou Med Univ, Guangzhou Peoples Hosp 8, Guangzhou, Peoples R China
[3] Hebei Anim Dis Control Ctr, Shijiazhuang, Peoples R China
[4] Fudan Univ, Shanghai Inst Infect Dis & Biosecur, Sch Pharm, Shanghai 201203, Peoples R China
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
Influenza A virus; Avian influenza virus; Surveillance; North China; H3N3; EVOLUTION; POULTRY; FLYWAYS; SPREAD;
D O I
10.1016/j.jinf.2024.106240
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Avian influenza remains a global public health concern for its well-known point mutation and genomic segment reassortment, through which plenty of serum serotypes are generated to escape existing immune protection in animal and human populations. Some occasional cases of human infection of avian influenza viruses (AIVs) since 2020 posed a potential pandemic risk through human-to-human transmission. Both east-west and north-south migratory birds fly through and linger in the Hebei Province of China as a stopover habitat, providing an opportunity for imported AIVs to infect the local poultry and for viral gene reassortment to generate novel stains. In this study, we collected more than 6000 environmental samples (mostly feces) in Hebei Province from 2021 to 2023. Samples were screened using real-time RT-PCR, and virus isolation was performed using the chick embryo culture method. We identified 10 AIV isolates, including a novel reassortant H3N3 isolate. Sequencing analysis revealed these AIVs are highly homologous to those isolated in the Yellow River Basin. Our findings supported that AIVs keep evolving to generate new isolates, necessitating a continuous risk assessment of local avian influenza in wild waterfowl in Hebei, China. (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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页数:8
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