As the operational velocity of high-speed railways significantly increases, the dynamic interplay among trains, route alignment, and track-bridge systems notably intensifies. To investigate the intricate relationships among track alignment, vehicles, and their underlying structures, as well as to identify suitable alignment parameters, this paper introduces a dynamic simulation model rooted in the principles of vehicle-track-bridge dynamic interactions. A variety of methods and metrics for assessing the comfort of train rides are compiled, and corresponding software is developed for verification. Three case studies illuminate the pragmatic application of dynamic analysis techniques in the determination of track alignment parameters, the adjustment of track geometry, and the compatibility of track-bridge structures. Furthermore, the design of high-speed railway lines is evaluated and refined. The findings of this research not only furnish theoretical and technical support for the crafting of high-speed railway tracks but also present practical instruments for enhancing the operational performance of trains and ensuring structural safety.