Investigating bilirubin concentrations in schizophrenia: A systematic review and meta-analysis

被引:1
作者
Coradduzza, Donatella [1 ]
di Lorenzo, Biagio [1 ]
Sedda, Stefania [1 ]
Nivoli, Alessandra Matilde [2 ,3 ]
Carru, Ciriaco [1 ,4 ]
Mangoni, Arduino A. [5 ,6 ]
Zinellu, Angelo [1 ]
机构
[1] Univ Sassari, Dept Biomed Sci, I-07100 Sassari, Italy
[2] Univ Sassari, Dept Med Surg & Pharm, Sassari, Italy
[3] Univ Hosp Sassari, Unit Urol, Sassari, Italy
[4] UO Oncol AOU Sassari, Sassari, Italy
[5] Southern Adelaide Local Hlth Network, Dept Clin Pharmacol, Adelaide, Australia
[6] Flinders Univ S Australia, Discipline Clin Pharmacol, Adelaide, Australia
关键词
Biomarkers; Bilirubin; Schizophrenia; Meta-analysis; Systematic review; Oxidative stress; Psychiatric disorders; BIAS; AGE;
D O I
10.1016/j.schres.2024.07.041
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Schizophrenia, a severe mental disorder characterized by chronic disability and poor quality of life, has been shown to be associated with alterations in redox balance. Recent research has suggested a potential link between the antioxidant bilirubin and schizophrenia, although findings have been inconsistent. To address this gap, we conducted a systematic review and meta-analysis to evaluate possible alterations in bilirubin concentrations in schizophrenia. A comprehensive search of major databases was conducted to identify articles reporting total and unconjugated bilirubin in schizophrenic patients and healthy controls in case-control studies. Our meta-analysis included 18 studies investigating 16,245 participants. The pooled results did not reveal any significant association between schizophrenia and total bilirubin concentrations. Additionally, such effect was strongly influenced by the results of a single study in sensitivity analysis. Subgroup and meta-regression analyses based on various factors such as study design, sample size, and geographical region showed no significant associations with the effect size, nor they identified sources of heterogeneity. Furthermore, publication bias assessments were conducted to ensure the robustness of the findings. Overall, our findings summarize the available evidence regarding the possible role of bilirubin as a biomarker of schizophrenia and highlight the importance of conducting further research in this area.
引用
收藏
页码:228 / 236
页数:9
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