The European Registry for Patients with Mechanical Circulatory Support (EUROMACS): fourth Paediatric EUROMACS (Paedi-EUROMACS) report

被引：0

作者：

Rohde, Sofie ^{[1
]}

van Puyvelde, Joeri ^{[2
]}

Veen, Kevin M. ^{[1
,8
]}

Schweiger, Martin ^{[3
]}

Biermann, Daniel ^{[4
]}

Amodeo, Antonio ^{[5
,6
]}

Martens, Thomas ^{[7
]}

Damman, Kevin

Gollmann-Tepekoylu, Can ^{[9
]}

Hulman, Michael ^{[10
]}

Iacovoni, Attilio ^{[11
]}

Kramer, Ulrike S. ^{[12
]}

Loforte, Antonio ^{[13
,14
]}

Pace Napoleone, Carlo ^{[15
]}

Nemec, Petr ^{[16
,17
]}

Netuka, Ivan ^{[18
]}

Ozbaran, Mustafa ^{[19
]}

Polo, Luz ^{[20
]}

Pya, Yuriy ^{[21
]}

Ramjankhan, Faiz ^{[22
]}

Sandica, Eugen ^{[23
]}

Sliwka, Joanna ^{[24
]}

Stiller, Brigitte ^{[25
]}

Kadner, Alexander ^{[26
]}

Franceschini, Alessio ^{[27
]}

Thiruchelvam, Timothy ^{[28
]}

Zimpfer, Daniel ^{[29
]}

Berger, Felix ^{[30
]}

Davies, Ben ^{[31
]}

Dashkevich, Alexey ^{[32
]}

Stark, Christoffer ^{[33
]}

Meyns, Bart

de By, Theo M. M. H. ^{[34
]}

Miera, Oliver ^{[30
]}

机构：

[1] Erasmus Univ, Med Ctr, Dept Cardiothorac Surg, Dr Molewaterpl 40, NL-3015 GD Rotterdam, Netherlands

[2] Katholieke Univ Leuven, Dept Cardiac Surg, Louvain, Belgium

[3] Childrens Hosp, Dept Congenital Pediat Surg, Zurich, Switzerland

[4] Univ Heart & Vasc Ctr Hamburg, Dept Congenital & Pediat Heart Surg, Childrens Heart Clin, Hamburg, Germany

[5] Univ Cattolica Sacro Cuore, Dept Cardiovasc & Pneumol Sci, Rome, Italy

[6] IRCCS, Bambino Gesu Childrens Hosp, Dept Cardiovasc & Pneumol Sci, Rome, Italy

[7] Ghent Univ Hosp, Dept Cardiac Surg, Ghent, Belgium

[8] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands

[9] Med Univ Innsbruck, Dept Cardiac Surg, Innsbruck, Austria

[10] Comenius Univ, Klinika Kardiochirurg NUSCH, Fac Med, Bratislava, Slovakia

[11] Osped Papa Giovanni XIII, Cardiovasc Dept, Bergamo, Italy

[12] Erasmus MC, Dept Pediat & Neonatal Intens Care, Div Pediat Intens Care, Sophia Childrens Hosp, Rotterdam, Netherlands

[13] IRCCS Bologna, St Orsola Univ Hosp, Dept Cardiac Surg, Bologna, Italy

[14] Univ Turin, Dept Surg Sci, Turin, Italy

[15] Regina Margher Childrens Hosp, Pediat & Congenital Cardiac Surg, Turin, Italy

[16] Ctr Cardiovasc Surg & Transplantat, Brno, Czech Republic

[17] Masaryk Univ, Fac Med, Dept Cardiac Surg & Transplantat Brno, Brno, Czech Republic

[18] Inst Clin & Expt Med IKEM, Dept Cardiovasc Surg, Prague, Czech Republic

[19] Ege Univ Hosp, Dept Cardiovasc Surg, Izmir, Turkiye

[20] La Paz Univ Hosp, Dept Congenital Cardiac Surg, Madrid, Spain

[21] Natl Res Cardiac Surg Ctr, Dept Cardiac Surg, Astana, Kazakhstan

[22] Univ Utrecht, Dept Thorac Surg, Med Ctr, Utrecht, Netherlands

[23] Heart & Diabet Ctr North Rhine Westphalia, Dept Surg Congenital Heart Defects, Clin Pediat Cardiac Surg & Congenital Heart Defec, Bad Oeynhausen, Germany

[24] Med Univ Silesia, Silesian Ctr Heart Dis, Dept Cardiac Surg Transplantol & Vasc Surg, Zabrze, Poland

[25] Univ Freiburg, Univ Heart Ctr Freiburg Bad Krozingen, Dept Congenital Heart Defects & Pediat Cardiol, Freiburg, Germany

[26] Univ Bern, Bern Univ Hosp, Ctr Congenital Heart Dis, Dept Cardiac Surg,Inselspital, Bern, Switzerland

[27] Bambino Gesu Pediat Hosp, Div Heart Failure Cardiothorac Transplantat & Mec, Rome, Italy

[28] Great Ormond St Hosp Sick Children, Heart & Lung Directorate, London, England

[29] Vienna Med Univ, Dept Cardiac Surg, Vienna, Austria

[30] Charite Univ Med Berlin, Dept Congenital Heart Dis Pediat Cardiol, Deutsch Herzzentrum Charite, Berlin, Germany

[31] Royal Childrens Hosp, Pediat Cardiac Surg Dept, Melbourne, Australia

[32] Univ Leipzig, Dept Cardiac Surg, Heart Ctr Leipzig, Leipzig, Germany

[33] Helsinki Univ Hosp, Dept Cardiac Surg, Helsinki, Finland

[34] EUROMACS, EACTS House, Windsor, England

来源：

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY | 2024年 / 66卷 / 02期

关键词：

Mechanical circulatory support; Ventricular assist device; Paediatric; Transplantation; EUROMACS; INTERAGENCY REGISTRY;

D O I：

10.1093/ejcts/ezae276

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVES: The use of ventricular assist devices (VADs) in children is increasing. However, absolute numbers in individual centres and countries remain small. Collaborative efforts such as the Paedi-European Registry for Patients with Mechanical Circulatory Support (EUROMACS) are therefore essential for combining international experience with paediatric VADs. Our goal was to present the results from the fourth Paedi-EUROMACS report. METHODS: All paediatric (<19 years) patients from the EUROMACS database supported by a VAD were included. Patients were stratified into a congenital heart disease (CHD) group and a group with a non-congenital aetiology. End points included mortality, a transplant and recovery. Cox proportional hazard models were used to explore associated factors for mortality, cerebrovascular accident and pump thrombosis. RESULTS: A total of 590 primary implants were included. The congenital group was significantly younger (2.5 vs 8.0 years, respectively, P < 0.001) and was more commonly supported by a pulsatile flow device (73.5% vs 59.9%, P < 0.001). Mortality was significantly higher in the congenital group (30.8% vs 20.4%, P = 0.009) than in the non-congenital group. However, in multivariable analyses, CHD was not significantly associated with mortality [hazard ratio (HR) 1.285; confidence interval (CI) 0.8111-2.036, P = 0.740]. Pump thrombosis was the most frequently reported adverse event (377 events in 132 patients; 0.925 events per patient-year) and was significantly associated with body surface area (HR 0.524, CI 0.333-0.823, P = 0.005), CHD (HR 1.641, CI 1.054-2.555, P = 0.028) and pulsatile flow support (HR 2.345, CI 1.406-3.910, P = 0.001) in multivariable analyses. CONCLUSIONS: This fourth Paedi-EUROMACS report highlights the increasing use of paediatric VADs. The patient populations with congenital and non-congenital aetiologies exhibit distinct characteristics and clinical outcomes.

引用

页数：12

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