Development and method validation for determination of acrylamide in food by modified QuEChERS and UHPLC-MS/MS analysis

被引：0
作者：
Cossu, Maurizio [1 ]
Sanna, Andrea [1 ]
Ledda, Giuseppe [1 ]
Chessa, Giannina [1 ]
Mangano, Giuseppe [1 ]
机构：
[1] Ist Zooprofilatt Sperimentale Sardegna G Pegreffi, Via Vienna 2, I-07100 Sassari, SS, Italy
来源：
JOURNAL OF FOOD COMPOSITION AND ANALYSIS | 2024年 / 135卷
关键词：
Acrylamide; LC-MS/MS; Method validation; Food processing;
D O I：
10.1016/j.jfca.2024.106698
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A newly developed method, combining the QuEChERS technique and LC-MS/MS system, has been successfully validated for the quantification of Acrylamide (AA) in various food samples. Compared to the existing methods, this approach offers a lower Limit of Quantification (LoQ) of 1 mu g/kg for a wide variety of foods studied. Repeatability was <3 % with a pooled RSDr% for peanuts, biscuits and crackers, while reproducibility for all matrices was good, with a pooled RSDR%<4 %. The method achieved an average recovery of 99 %, indicating effective extraction and determination of AA. Validation results meet established performance criteria required for AA program control as defined by Commission Implementing Regulation (EU) 2019/2093.
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页数：4
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