CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer's disease

被引：2

作者：

Delvenne, Aurore ^{[1
]}

Gobom, Johan ^{[2
,3
]}

Schindler, Suzanne E. ^{[4
,5
]}

ten Kate, Mara ^{[6
,7
]}

Reus, Lianne M. ^{[6
]}

Dobricic, Valerija ^{[8
]}

Tijms, Betty M. ^{[6
]}

Benzinger, Tammie L. S. ^{[9
]}

Cruchaga, Carlos ^{[10
]}

Teunissen, Charlotte E. ^{[11
]}

Ramakers, Inez ^{[1
]}

Martinez-Lage, Pablo ^{[12
]}

Tainta, Mikel ^{[12
]}

Vandenberghe, Rik ^{[13
,14
]}

Schaeverbeke, Jolien ^{[13
,14
]}

Engelborghs, Sebastiaan ^{[15
,16
,17
,18
]}

De Roeck, Ellen ^{[15
,19
,20
]}

Popp, Julius ^{[21
,22
]}

Peyratout, Gwendoline ^{[21
]}

Tsolaki, Magda ^{[23
]}

Freund-Levi, Yvonne ^{[24
,25
,26
,27
]}

Lovestone, Simon ^{[28
,29
]}

Streffer, Johannes ^{[15
,30
]}

Barkhof, Frederik ^{[6
,31
,32
]}

Bertram, Lars ^{[8
]}

Blennow, Kaj ^{[2
,3
,33
,34
,35
,36
]}

Zetterberg, Henrik ^{[2
,3
,37
,38
,39
,40
]}

Visser, Pieter Jelle ^{[1
,6
,41
]}

Vos, Stephanie J. B. ^{[1
]}

机构：

[1] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Alzheimer Ctr Limburg, POB 616, NL-6200 MD Maastricht, Netherlands

[2] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

[3] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden

[4] Washington Univ, Sch Med, Dept Neurol, St Louis, MO USA

[5] Washington Univ, Sch Med, Knight Alzheimers Dis Res Ctr, St Louis, MO USA

[6] Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands

[7] Vrije Univ Amsterdam, Dept Radiol & Nucl Med, Amsterdam Neurosci, Amsterdam UMC, Amsterdam, Netherlands

[8] Univ Lubeck, Lubeck Interdisciplinary Platform Genome Analyt, Lubeck, Germany

[9] Washington Univ, Sch Med, Dept Radiol, St Louis, MO USA

[10] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO USA

[11] Univ Amsterdam, Dept Clin Chem, Neurochem Lab, Amsterdam Neurosci,Med Ctr AUMC, Amsterdam, Netherlands

[12] Fdn CITA Alzheimer Fundazioa, Donostia San Sebastian, Spain

[13] Univ Hosp Leuven, Neurol Serv, Leuven, Belgium

[14] Katholieke Univ Leuven, Dept Neurosci, Lab Cognit Neurol, Leuven, Belgium

[15] Univ Antwerp, Reference Ctr Biol Markers Dementia BIODEM, Dept Biomed Sci, Antwerp, Belgium

[16] Univ Ziekenhuis Brussel, Dept Neurol, Brussels, Belgium

[17] Univ Ziekenhuis Brussel, Bru BRAIN, Brussels, Belgium

[18] Vrije Univ Brussel, Ctr Neurosci C4N, NEUR Res Grp, Brussels, Belgium

[19] Hosp Network Antwerp ZNA Middelheim & Hoge Beuken, Dept Neurol, Antwerp, Belgium

[20] Hosp Network Antwerp ZNA Middelheim & Hoge Beuken, Memory Clin, Antwerp, Belgium

[21] Univ Hosp Lausanne, Old Age Psychiat, Lausanne, Switzerland

[22] Psychiat Univ Hosp Zurich, Dept Psychiat Psychotherapy & Psychosomat, Zurich, Switzerland

[23] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Fac Hlth Sci, Med Sch,Dept Neurol 1, Thessaloniki, Makedonia, Greece

[24] Karolinska Inst, Div Clin Geriatr, Dept Neurobiol Caring Sci & Soc NVS, Huddinge, Stockholm, Sweden

[25] Orebro Univ, Fac Med & Hlth, Dept Psychiat Reg Orebro Cty, Orebro, Sweden

[26] Orebro Univ, Fac Med & Hlth, Sch Med Sci, Orebro, Sweden

[27] Kings Coll London, Dept Old Age Psychiat Psychol & Neurosci, London, England

[28] Univ Oxford, Oxford, England

[29] Johnson & Johnson Med Ltd, Oxford, England

[30] H Lundbeck A S, Valby, Denmark

[31] UCL, Queen Sq Inst Neurol, London, England

[32] UCL, Ctr Med Image Comp, London, England

[33] Sorbonne Univ, Pitie Salpetriere Hosp, Paris Brain Inst, ICM, Paris, France

[34] Univ Sci & Technol China, Inst Aging & Brain Disorders, Neurodegenerat Disorder Res Ctr, Div Life Sci & Med, Hefei, Peoples R China

[35] Univ Sci & Technol China, Inst Aging & Brain Disorders, Dept Neurol, Hefei, Peoples R China

[36] First Affiliated Hosp USTC, Hefei, Peoples R China

[37] UCL, Dept Neurodegenerat Dis, Inst Neurol, London, England

[38] UCL, UK Dementia Res Inst, London, England

[39] Hong Kong Ctr Neurodegenerat Dis, Clear Water Bay, Hong Kong, Peoples R China

[40] Univ Wisconsin, Wisconsin Alzheimers Dis Res Ctr, Sch Med & Publ Hlth, Madison, WI USA

[41] Karolinska Inst, Div Neurogeriatr, Dept Neurobiol Care Sci & Soc, Huddinge, Stockholm, Sweden

来源：

ALZHEIMERS & DEMENTIA | 2024年 / 20卷 / 09期

关键词：

Alzheimer's disease; biomarkers; cerebrospinal fluid; hippocampal volume; neurodegeneration markers; neurofilament light; neurogranin; pathophysiology; proteomics; CEREBROSPINAL-FLUID; COGNITIVE IMPAIRMENT; NEUROGRANIN; ASSOCIATION; EXPRESSION; ADULT; MODEL; RISK; TAU;

D O I：

10.1002/alz.14103

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: We aimed to unravel the underlying pathophysiology of the neurodegeneration (N) markers neurogranin (Ng), neurofilament light (NfL), and hippocampal volume (HCV), in Alzheimer's disease (AD) using cerebrospinal fluid (CSF) proteomics. METHODS: Individuals without dementia were classified as A+ (CSF amyloid beta [A beta]42), T+ (CSF phosphorylated tau181), and N+ or N- based on Ng, NfL, or HCV separately. CSF proteomics were generated and compared between groups using analysis of covariance. RESULTS: Only a few individuals were A+T+Ng-. A+T+Ng+ and A+T+NfL+ showed different proteomic profiles compared to A+T+Ng- and A+T+NfL-, respectively. Both Ng+ and NfL+ were associated with neuroplasticity, though in opposite directions. Compared to A+T+HCV-, A+T+HCV+ showed few proteomic changes, associated with oxidative stress. DISCUSSION: Different N markers are associated with distinct neurodegenerative processes and should not be equated. N markers may differentially complement disease staging beyond amyloid and tau. Our findings suggest that Ng may not be an optimal N marker, given its low incongruency with tau pathophysiology.

引用

页码：6205 / 6220

页数：16

共 68 条

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