Racial and ethnic differences in epithelial ovarian cancer risk: an analysis from the Ovarian Cancer Association Consortium

被引：2

作者：

Meagher, Nicola S. ^{[1
,2
]}

White, Kami K. ^{[3
]}

Wilkens, Lynne R. ^{[3
]}

Bandera, Elisa, V ^{[4
]}

Berchuck, Andrew ^{[5
]}

Carney, Michael E. ^{[6
]}

Cramer, Daniel W. ^{[7
,8
,9
]}

Cushing-Haugen, Kara L. ^{[10
]}

Jordan, Susan ^{[11
]}

Kaufmann, Scott H. ^{[12
,13
,14
]}

Le, Nhu D. ^{[15
]}

Pike, Malcolm C. ^{[16
,17
]}

Riggan, Marjorie ^{[5
]}

Qin, Bo ^{[4
]}

Rothstein, Joseph H. ^{[18
,19
]}

Titus, Linda ^{[20
]}

Winham, Stacey J. ^{[21
]}

Anton-Culver, Hoda ^{[22
]}

Doherty, Jennifer A. ^{[23
]}

Goode, Ellen L. ^{[24
]}

Pearce, Celeste Leigh ^{[25
]}

Risch, Harvey A. ^{[26
]}

Webb, Penelope M. ^{[27
]}

Cook, Linda S. ^{[28
,29
]}

Goodman, Marc T. ^{[30
]}

Harris, Holly R. ^{[10
,31
]}

Le Marchand, Loic ^{[32
]}

McGuire, Valerie ^{[33
]}

Pharoah, Paul D. P. ^{[34
,35
]}

Sarink, Danja ^{[3
]}

Schildkraut, Joellen M. ^{[36
]}

Sieh, Weiva ^{[18
,19
]}

Terry, Kathryn L. ^{[7
,8
,9
]}

Thompson, Pamela J. ^{[37
]}

Whittemore, Alice S. ^{[35
,38
]}

Wu, Anna H. ^{[17
]}

Peres, Lauren C. ^{[39
]}

Merritt, Melissa A. ^{[1
]}

机构：

[1] Univ Sydney, Daffodil Ctr, Joint Venture Canc Council NSW, Sydney, NSW, Australia

[2] Univ NSW Sydney, Sch Clin Med, UNSW Med & Hlth, Sydney, NSW, Australia

[3] Univ Hawaii, Canc Epidemiol Program, Canc Ctr, Honolulu, HI USA

[4] Rutgers Canc Inst New Jersey, Canc Prevent & Control Program, New Brunswick, NJ USA

[5] Duke Univ, Dept Obstet & Gynecol, Div Gynecol Oncol, Med Ctr, Durham, NC USA

[6] Univ Hawaii, John A Burns Sch Med, Dept Obstet & Gynecol, Honolulu, HI USA

[7] Brigham & Womens Hosp, Obstet & Gynecol Epidemiol Ctr, Boston, MA USA

[8] Harvard Med Sch, Boston, MA USA

[9] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[10] Fred Hutchinson Canc Ctr, Program Epidemiol, Div Publ Hlth Sci, Seattle, WA USA

[11] Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia

[12] Mayo Clin, Dept Oncol, Rochester, MN USA

[13] Mayo Clin, Dept Pharmacol, Rochester, MN USA

[14] Mayo Clin, Dept Med, Rochester, MN USA

[15] BC Canc Res Ctr, Canc Control Res, Vancouver, BC, Canada

[16] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY USA

[17] Univ Southern Calif, Keck Sch Med, Dept Populat & Publ Hlth Sci, Norris Comprehens Canc Ctr, Los Angeles, CA USA

[18] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY USA

[19] Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, New York, NY USA

[20] Univ Southern Maine, Muskie Sch Publ Serv, Publ Hlth, Portland, ME USA

[21] Mayo Clin, Dept Quantitat Hlth Sci, Div Computat Biol, Rochester, MN USA

[22] Univ Calif Irvine, Genet Epidemiol Res Inst, Dept Med, Irvine, CA USA

[23] Univ Utah, Huntsman Canc Inst, Dept Populat Hlth Sci, Salt Lake City, UT USA

[24] Mayo Clin, Dept Quantitat Hlth Sci, Div Epidemiol, Rochester, MN USA

[25] Univ Michigan, Dept Epidemiol, Sch Publ Hlth, Ann Arbor, MI USA

[26] Yale Sch Publ Hlth, Chron Dis Epidemiol, New Haven, CT USA

[27] QIMR Berghofer Med Res Inst, Populat Hlth Program, Brisbane, Qld, Australia

[28] Univ Colorado, Sch Publ Hlth, Epidemiol, Aurora, CO USA

[29] Univ Calgary, Community Hlth Sci, Calgary, AB, Canada

[30] Cedars Sinai Med Ctr, Canc Prevent & Control Program, Los Angeles, CA USA

[31] Univ Washington, Dept Epidemiol, Seattle, WA USA

[32] Univ Hawaii, Epidemiol Program, Canc Ctr, Honolulu, HI USA

[33] Stanford Univ, Dept Epidemiol & Populat Hlth, Sch Med, Stanford, CA USA

[34] Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England

[35] Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England

[36] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA USA

[37] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Canc Prevent & Genet Program, Los Angeles, CA USA

[38] Stanford Univ, Sch Med, Dept Biomed Data Sci, Stanford, CA USA

[39] H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 2024年 / 193卷 / 09期

基金：

美国国家卫生研究院; 英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

ovarian cancer; risk factors; race; ethnicity; POOLED ANALYSIS; SUBTYPES;

D O I：

10.1093/aje/kwae076

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Limited estimates exist on risk factors for epithelial ovarian cancer (EOC) in Asian, Hispanic, and Native Hawaiian/Pacific Islander women. Participants in this study included 1734 Asian (n = 785 case and 949 control participants), 266 Native Hawaiian/Pacific Islander (n = 99 case and 167 control participants), 1149 Hispanic (n = 505 case and 644 control participants), and 24 189 White (n = 9981 case and 14 208 control participants) from 11 studies in the Ovarian Cancer Association Consortium. Logistic regression models estimated odds ratios (ORs) and 95% CIs for risk associations by race and ethnicity. Heterogeneity in EOC risk associations by race and ethnicity (P <= .02) was observed for oral contraceptive (OC) use, parity, tubal ligation, and smoking. We observed inverse associations with EOC risk for OC use and parity across all groups; associations were strongest in Native Hawaiian/Pacific Islander and Asian women. The inverse association for tubal ligation with risk was most pronounced for Native Hawaiian/Pacific Islander participants (odds ratio (OR) = 0.25; 95% CI, 0.13-0.48) compared with Asian and White participants (OR = 0.68 [95% CI, 0.51-0.90] and OR = 0.78 [95% CI, 0.73-0.85], respectively). Differences in EOC risk factor associations were observed across racial and ethnic groups, which could be due, in part, to varying prevalence of EOC histotypes. Inclusion of greater diversity in future studies is essential to inform prevention strategies.This article is part of a Special Collection on Gynecological Cancers.

引用

页码：1242 / 1252

页数：11

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