Carnitine analysis in food and biological samples: Chromatography and mass spectrometry insights

被引:0
|
作者
Cheng, Bing [1 ]
Li, Kaixuan [1 ]
Li, Wenxuan [1 ]
Liu, Yuwei [1 ]
Zheng, Yuanyuan [1 ]
Zhang, Qinfeng [1 ,2 ,3 ]
Chen, Di [1 ,4 ]
机构
[1] Zhengzhou Univ, Sch Pharmaceut Sci, Natl Key Lab Cotton Biobreeding & Integrated Utili, Zhengzhou Res Base, Zhengzhou 450001, Peoples R China
[2] Hubei Geol Bur, Hubei Geol Res Lab, Hubei Key Lab Resources & Ecoenvironm Geol, Wuhan 430034, Peoples R China
[3] Wuhan Inst Food & Cosmet Control, Key Lab Edible Oil Qual & Safety State Market Regu, Wuhan 430040, Peoples R China
[4] Key Lab Targeting Therapy & Diag Crit Dis Henan Pr, Zhengzhou 450001, Peoples R China
基金
中国博士后科学基金;
关键词
Carnitines; Food; Biological sample; Analytical method; Chromatography; Mass spectrometry; ACETYL-L-CARNITINE; URINARY ACYLCARNITINES; ION CHROMATOGRAPHY; MILK SAMPLES; PAPER SPRAY; PLASMA; EXTRACTION; MS/MS; QUANTIFICATION; IDENTIFICATION;
D O I
10.1016/j.arabjc.2024.105818
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Carnitines, essential for human metabolism and fatty acid transport, are primarily obtained from the diet. Inadequate synthesis or intake can lead to serious metabolic disorders, which may result in fatal outcomes. Therefore, the accurate determination of carnitines in both food and biological samples is of high importance. However, these samples are inherently complex and require meticulous preparation procedures before determination. This step is critical for enhancing the sensitivity and precision of the detection process. Moreover, the selection of an appropriate detection method is crucial and must match the analytes' characteristics. For example, since carnitines lack chromophores for spectroscopic detection, they require derivatization to become spectroscopically visible. Among the various methods available for carnitine determination, chromatography and mass spectrometry are the most prominent, owing to their superior selectivity and sensitivity. Nonetheless, there seems to be a lack of comprehensive reviews on this subject. Consequently, this article aims to compile the latest advancements in analytical methodologies for carnitines over the past decade (2013-2023), with a particular emphasis on the crucial contributions of chromatography and mass spectrometry techniques. This review provides crucial insights for metabolic research, underpinning advances in understanding carnitine's metabolic roles. It aims to highlight current innovations in carnitine analysis and inspire future breakthroughs impacting nutrition, diagnostics, and therapy.
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页数:15
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