Evaluation of EUCAST rapid antimicrobial susceptibility test directly from positive blood culture for Pseudomonas aeruginosa

被引：0
作者：
Lebreton, Cedric [1 ]
Fournier, Damien [1 ,2 ]
Jeannot, Katy [1 ,2 ,3 ]
机构：
[1] Ctr Hosp Univ Besancon, Lab Bacteriol, Blvd Fleming, F-25000 Besancon, France
[2] Ctr Hosp Univ Besancon, Lab Associe, Ctr Natl Reference Resistance Antibiot, F-25000 Besancon, France
[3] Univ Franche Comte, Chronoenvironm UMR 6249, CNRS, F-25000 Besancon, France
来源：
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2024年 / 43卷 / 10期
关键词：
Pseudomonas aeruginosa; RAST; Antibiotic susceptibility testing; Blood culture;
D O I：
10.1007/s10096-024-04895-8
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
In this study, we evaluated the performance of the EUCAST RAST method on a collection of 154 clinical strains of P. aeruginosa, including strains resistant to ceftazidime and carbapenems. While the test is convenient for routine laboratories, we observed significant rates of VME (ranging from 0.0 to 15.0%) and ME (ranging from 1.3 to 16.3%) after 6 h, particularly for key antibiotics such as ceftazidime, piperacillin/tazobactam, and meropenem. Extending the incubation time to 8 h may improve results (CA ranging from 87.2 to 99%), but caution is required in interpretation due to persistence of VME (ranging from 0.0 to 15.6%) and ME (ranging from 0.0 to 11.7%).
引用
收藏
页码：2061 / 2064
页数：4
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